{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:24:14Z","timestamp":1791192254966,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Placental<jats:italic>Plasmodium falciparum<\/jats:italic>infection affects birth outcomes and sensitizes fetal lymphocytes to parasite antigens. We assessed the influence of maternal<jats:italic>P. falciparum<\/jats:italic>infection on fetal myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC), analyzing the cord blood of offspring of Gabonese mothers with different infection histories. Cord blood from newborns of mothers with malarial infection at delivery had significantly more mDC than that from nonexposed newborns (<jats:italic>P<\/jats:italic>= 0.028) but mDC and pDC HLA-DR expression was unrelated to maternal infection history. Independently of these findings, cord blood mDC and pDC numbers declined significantly as a function of increasing maternal age (<jats:italic>P<\/jats:italic>= 0.029 and<jats:italic>P<\/jats:italic>= 0.033, respectively). The inducible antigen-specific interleukin-10-producing regulatory-type T-cell population that we have previously detected in cord blood of newborns with prolonged in utero exposure to<jats:italic>P. falciparum<\/jats:italic>may directly reflect the altered DC numbers in such neonates, while the maintenance of cord blood DC HLA-DR expression contrasts with that of DC from<jats:italic>P. falciparum<\/jats:italic>malaria patients.<\/jats:p>","DOI":"10.1128\/iai.00682-06","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T23:06:35Z","timestamp":1158793595000},"page":"5725-5729","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Cord Blood Dendritic Cell Subsets in African Newborns Exposed to<i>Plasmodium falciparum<\/i>In Utero"],"prefix":"10.1128","volume":"74","author":[{"given":"Lutz P.","family":"Breitling","sequence":"first","affiliation":[{"name":"Medical Research Unit, Albert Schweitzer Hospital, Lambare\u0301ne\u0301, Gabon"},{"name":"Institute for Tropical Medicine, Department of Parasitology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Fendel","sequence":"additional","affiliation":[{"name":"Medical Research Unit, Albert Schweitzer Hospital, Lambare\u0301ne\u0301, Gabon"},{"name":"Institute for Tropical Medicine, Department of Parasitology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mordmueller","sequence":"additional","affiliation":[{"name":"Medical Research Unit, Albert Schweitzer Hospital, Lambare\u0301ne\u0301, Gabon"},{"name":"Institute for Tropical Medicine, Department of Parasitology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayola A.","family":"Adegnika","sequence":"additional","affiliation":[{"name":"Medical Research Unit, Albert Schweitzer Hospital, Lambare\u0301ne\u0301, Gabon"},{"name":"Institute for Tropical Medicine, Department of Parasitology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"},{"name":"Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Kremsner","sequence":"additional","affiliation":[{"name":"Medical Research Unit, Albert Schweitzer Hospital, Lambare\u0301ne\u0301, Gabon"},{"name":"Institute for Tropical Medicine, Department of Parasitology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J. F.","family":"Luty","sequence":"additional","affiliation":[{"name":"Medical Research Unit, Albert Schweitzer Hospital, Lambare\u0301ne\u0301, Gabon"},{"name":"Institute for Tropical Medicine, Department of Parasitology, University of Tu\u0308bingen, Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2003.10.019"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.12.7988-7995.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/498578"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1738"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf192"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2003.11.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6037"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/429336"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.4049\/jimmunol.160.5.2523","volume":"160","year":"1998","unstructured":"Fried, M., R. O. Muga, A. O. Misore, and P. E. Duffy. 1998. Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes. J. Immunol.160:2523-2530.","journal-title":"J. Immunol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.2141"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02243.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0715-3"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01817.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009200"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0097"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.6.3462-3470.2005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol34"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020407"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00771.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4926"},{"key":"e_1_3_2_23_2","first-page":"9","volume":"91","year":"2002","unstructured":"Schibler, K. R., A. Georgelas, and A. Rigaa. 2002. Developmental biology of the dendritic cell system. Acta Paediatr. Suppl.91:9-16.","journal-title":"Acta Paediatr. Suppl."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052450"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0369-8114(03)00096-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00772.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2003.08.342"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/21900"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.4.1986-1994.2005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2859"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol37"},{"key":"e_1_3_2_32_2","first-page":"77","volume":"46","year":"1995","unstructured":"Wildling, E., S. Winkler, P. G. Kremsner, C. Brandts, L. Jenne, and W. H. Wernsdorfer. 1995. Malaria epidemiology in the province of Moyen Ogoov, Gabon. Trop. Med. Parasitol.46:77-82.","journal-title":"Trop. Med. Parasitol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1300"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00682-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00682-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T15:45:54Z","timestamp":1707234354000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00682-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1128\/IAI.00682-06"],"URL":"https:\/\/doi.org\/10.1128\/iai.00682-06","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"2006-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}