{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:39:49Z","timestamp":1791329989718,"version":"4.3.1"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Some clinical isolates of\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            produce the superantigenic toxic shock syndrome toxin 1 (TSST-1), encoded by\n            <jats:italic>tst<\/jats:italic>\n            , located on pathogenicity islands. The expression of\n            <jats:italic>tst<\/jats:italic>\n            is complex and is influenced by environmental conditions such as pH, CO\n            <jats:sub>2<\/jats:sub>\n            , and glucose. We identified a putative catabolite-responsive element (\n            <jats:italic>cre<\/jats:italic>\n            ) in the promoter regions of all known\n            <jats:italic>tst<\/jats:italic>\n            genes, indicating that\n            <jats:italic>tst<\/jats:italic>\n            transcription may be regulated by the catabolite control protein CcpA. By introducing\n            <jats:italic>tst<\/jats:italic>\n            genes under the control of their native promoters or\n            <jats:italic>tst<\/jats:italic>\n            promoter-reporter gene fusions in wild-type strain Newman, we showed that glucose was able to repress\n            <jats:italic>tst<\/jats:italic>\n            transcription and TSST-1 production, whereas glucose repression was abolished in the corresponding \u0394\n            <jats:italic>ccpA<\/jats:italic>\n            mutant. Stabilizing the pH ruled out a pH effect due to acid production during glucose catabolism. CcpA thus directly regulates\n            <jats:italic>tst<\/jats:italic>\n            transcription, linking carbohydrate utilization to virulence gene expression in\n            <jats:italic>S. aureus<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/iai.00724-08","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T00:34:20Z","timestamp":1219106060000},"page":"5093-5099","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":75,"title":["CcpA Mediates the Catabolite Repression of\n            <i>tst<\/i>\n            in\n            <i>Staphylococcus aureus<\/i>"],"prefix":"10.1128","volume":"76","author":[{"given":"Kati","family":"Seidl","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Zu\u0308rich, Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bischoff","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Zu\u0308rich, Zu\u0308rich, Switzerland"},{"name":"Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, Homburg\/Saar, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Berger-Ba\u0308chi","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Zu\u0308rich, Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.17.5171-5179.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66787-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-9-2469"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.23.6232-6241.1998"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.10.6076-6085.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00309-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012183032501"},{"key":"e_1_3_2_9_2","first-page":"37","volume":"27","year":"2008","unstructured":"Descloux, E., T. 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