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We previously characterized the virulence of\n                      <jats:italic toggle=\"yes\">B. pseudomallei<\/jats:italic>\n                      wild-type ATS2021 (\n                      <jats:italic toggle=\"yes\">\n                        bimA\n                        <jats:sub>Bm<\/jats:sub>\n                      <\/jats:italic>\n                      ). In a mouse model of ATS2021 aerosol exposure, lesions and inflammatory cytokines in the brain were seen early post-exposure and reached the central nervous system (CNS) through the olfactory nerve. In the current study, the\n                      <jats:italic toggle=\"yes\">bimA<\/jats:italic>\n                      allele in the wild-type ATS2021 was replaced with the\n                      <jats:italic toggle=\"yes\">\n                        bimA\n                        <jats:sub>Bp<\/jats:sub>\n                      <\/jats:italic>\n                      , and virulence was assessed by estimations of LD\n                      <jats:sub>50<\/jats:sub>\n                      , histopathological analyses, and bacterial dissemination. ATS2021\n                      <jats:italic toggle=\"yes\">\n                        bimA\n                        <jats:sub>Bp<\/jats:sub>\n                      <\/jats:italic>\n                      reached the CNS but was significantly attenuated, with higher LD\n                      <jats:sub>50<\/jats:sub>\n                      estimates, altered bacterial dissemination, and reduced neuroinflammation. The immune response in lungs, spleens, and brains from mice exposed to aerosols indicated either strain induced shared and divergent immune patterns. Finally, the evaluation of the host response in brains via NanoString transcriptomic platform analyses suggested that the wild-type ATS2021 induced substantial changes in astrocyte and microglial activation, oligodendrocyte function, and overall inflammatory signaling, compared to the mutant\n                      <jats:italic toggle=\"yes\">\n                        bimA\n                        <jats:sub>Bp<\/jats:sub>\n                      <\/jats:italic>\n                      bacteria. These results support a direct role of the\n                      <jats:italic toggle=\"yes\">\n                        bimA\n                        <jats:sub>Bm<\/jats:sub>\n                      <\/jats:italic>\n                      gene product for bacterial dissemination after inhalation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00727-25","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:53:41Z","timestamp":1781787221000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of an isogenic\n                    <i>bimA<\/i>\n                    mutant in the ATS2021 strain of\n                    <i>Burkholderia pseudomallei<\/i>"],"prefix":"10.1128","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0997-7584","authenticated-orcid":true,"given":"Christopher 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