{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:45:16Z","timestamp":1780105516654,"version":"3.54.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            CD11b\n            <jats:sup>+<\/jats:sup>\n            Gr1\n            <jats:sup>+<\/jats:sup>\n            myeloid-derived suppressor cells (MDSCs), a heterogeneous population of precursor cells, modulate protective immunity against visceral leishmaniasis by suppressing T cell functions. We observed that CD11b\n            <jats:sup>+<\/jats:sup>\n            Gr1\n            <jats:sup>+<\/jats:sup>\n            MDSCs, which initially expanded in soluble leishmanial antigen (SLA)-immunized mice and later diminished, suppressed proliferation of T cells isolated from SLA-immunized mice, but to a lesser extent than the case in naive mice. This lesser suppression of MDSCs accompanied the expression of F4\/80 and the production of Cox-2, arginase I, nitric oxide, and PGE2. However, with SLA immunization, there was no difference in the expression of interleukin-2 (IL-2) or gamma interferon (IFN-\u03b3) by T cells, in contrast to the case in nonimmunized mice, in which there is an influence. Glycyrrhizic acid (a triterpenoid compound)-mediated inhibition of Cox-2 in myeloid-derived suppressor cells influenced the capacity of T cells to proliferate and the expression of IL-2 and IFN-\u03b3 in\n            <jats:named-content content-type=\"genus-species\">Leishmania donovani<\/jats:named-content>\n            -infected BALB\/c mice. Further characterization confirmed that administration of glycyrrhizic acid to\n            <jats:named-content content-type=\"genus-species\">L. donovani<\/jats:named-content>\n            -infected BALB\/c mice results in an impairment of the generation of MDSCs and a reciprocal organ-specific proliferation of IFN-\u03b3- and IL-10-expressing CD4\n            <jats:sup>+<\/jats:sup>\n            and CD8\n            <jats:sup>+<\/jats:sup>\n            T cells. Comprehensive knowledge on the Cox-2-mediated regulation of myeloid-derived suppressor cells might be involved in unlocking a new avenue for therapeutic interventions during visceral leishmaniasis.\n          <\/jats:p>","DOI":"10.1128\/iai.00729-15","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T02:15:51Z","timestamp":1441764951000},"page":"4476-4486","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Glycyrrhizic Acid-Mediated Subdual of Myeloid-Derived Suppressor Cells Induces Antileishmanial Immune Responses in a Susceptible Host"],"prefix":"10.1128","volume":"83","author":[{"given":"Syamdas","family":"Bandyopadhyay","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine, Bose Institute, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Bose Institute, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayantan","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Bose Institute, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuntal","family":"Halder","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Bose Institute, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibali","family":"Das","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Bose Institute, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidisha","family":"Paul Chowdhury","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Bose Institute, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Bose Institute, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00213"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.01.009"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0505"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01378-13"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxf076"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3581"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5228"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1110608"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080669"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303408"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1668"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001684"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.04.011"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040911"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050715"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks159"},{"key":"e_1_3_3_19_2","volume-title":"Indian patent application 771\/KOL\/2005. 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