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C-reactive protein (CRP) is an acute-phase serum protein that has been shown to help protect the host from several bacterial pathogens, which it recognizes by binding to phosphorylcholine (PC) on their surfaces. Pathogenic<jats:italic>Neisseria<\/jats:italic>species can exhibit phase-variable PC modification on type 1 and 2 pili. We have shown that CRP can bind to piliated meningococci in a classical calcium-dependent manner. The binding of CRP to the meningococcus was concentration dependent, of low affinity, and specific for PC. CRP appears to act as an opsonin for<jats:italic>N. meningitidis<\/jats:italic>, as CRP-opsonized bacteria showed increased uptake by human macrophages and neutrophils. Further investigation into the downstream effects of CRP-bound<jats:italic>N. meningitidis<\/jats:italic>may lead us to a better understanding of meningococcal infection and help direct more effective therapeutic interventions.<\/jats:p>","DOI":"10.1128\/iai.00741-07","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T01:34:16Z","timestamp":1200360856000},"page":"1298-1304","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["The Acute-Phase Reactant C-Reactive Protein Binds to Phosphorylcholine-Expressing<i>Neisseria meningitidis<\/i>and Increases Uptake by Human Phagocytes"],"prefix":"10.1128","volume":"76","author":[{"given":"Rosalyn","family":"Casey","sequence":"first","affiliation":[{"name":"Division of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford, Surrey GU2 7XH, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Newcombe","sequence":"additional","affiliation":[{"name":"Division of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford, Surrey GU2 7XH, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JohnJoe","family":"McFadden","sequence":"additional","affiliation":[{"name":"Division of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford, Surrey GU2 7XH, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine B.","family":"Bodman-Smith","sequence":"additional","affiliation":[{"name":"Division of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford, Surrey GU2 7XH, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(69)90177-3"},{"key":"e_1_3_2_3_2","first-page":"28","volume":"110","year":"2003","unstructured":"Bodman-Smith, K. 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