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Exacerbating this issue is the emergence of multi-drug-resistant strains, posing a major threat to human health. Type 5 secretion system proteins play a major role in virulence and are viable vaccine targets. However, only a limited number of these proteins have been functionally characterized to date. In this study, we characterized SeaB, which belongs to the Type 5a secretion system. We demonstrated that SeaB is localized to the cell surface and involved in binding to the extracellular matrix. Our results indicate that SeaB is involved in aggregation and biofilm formation and contributes to virulence. Furthermore, immunization with SeaB elicits antibodies and provides protection against\n                      <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                      challenge in a mouse model of infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00754-25","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:57:42Z","timestamp":1777571862000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["SeaB is a conserved\n                    <i>Salmonella enterica<\/i>\n                    extracellular matrix binding protein involved in biofilm formation and infection"],"prefix":"10.1128","volume":"94","author":[{"given":"Rochelle M.","family":"Da Costa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Rooke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-0452","authenticated-orcid":true,"given":"Faye C.","family":"Morris","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03angcq70","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Microbiology and Infection, University of Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng Jie","family":"Lian","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-7998","authenticated-orcid":true,"given":"Amanda E.","family":"Rossiter","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01x8c0495","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Immunology and Immunotherapy, University of Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Cole","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03angcq70","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Microbiology and Infection, University of Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-4785","authenticated-orcid":true,"given":"Brian","family":"Forde","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-964X","authenticated-orcid":true,"given":"Adam F.","family":"Cunningham","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01x8c0495","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Immunology and Immunotherapy, University of Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-4977","authenticated-orcid":true,"given":"Ian R.","family":"Henderson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61752-2"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29054"},{"key":"e_1_3_4_4_2","unstructured":"WHO. 2019. 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