{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:38:03Z","timestamp":1785418683380,"version":"3.56.0"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2026,6,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The cGAS-STING pathway is activated during chlamydial infection and plays a critical role in controlling\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      infection in the mouse lower genital tract. The current study evaluated whether intravaginal administration of exogenous STING agonists could inhibit chlamydial infection and attenuate upper genital tract pathologies in a mouse model of\n                      <jats:italic toggle=\"yes\">Chlamydia muridarum<\/jats:italic>\n                      infection. We found that both the STING agonists 2\u20323\u2032-cGAMP and diABZI significantly reduced the shedding of live chlamydial organisms recovered from the vaginal swabs and markedly decreased hydrosalpinx and inflammatory infiltrates induced by\n                      <jats:italic toggle=\"yes\">C. muridarum<\/jats:italic>\n                      , which are major pathological outcomes associated with tubal infertility in women infected with\n                      <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                      . Importantly, mice exhibited local and systemic tolerance to the STING agonists. Collectively, these findings suggest a novel STING agonist-based approach for controlling chlamydial infection, which could offer a non-antibiotic, mucosally targeted strategy to reduce the risk of hydrosalpinx in exposed women.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00761-25","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:19:51Z","timestamp":1777547991000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["STING agonists reduce genital chlamydial infection and attenuate inflammation and pathology"],"prefix":"10.1128","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8925-9111","authenticated-orcid":false,"given":"Xuemei","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009j0tv77","id-type":"ROR","asserted-by":"publisher"}],"name":"Experimental Center, Guizhou Center for 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