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As the generation of type 2 cytokine responses by the human trematode parasite<jats:italic>Schistosoma mansoni<\/jats:italic>is glycan mediated, there is a particular potential role for a C-type lectin receptor (CLR) to mediate the innate recognition of schistosome PAMPs. One such CLR, dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN; CD209), has been shown to recognize glycans expressed by<jats:italic>S. mansoni<\/jats:italic>eggs. We show that SIGNR1 (SIGN-related 1; CD209b), a murine homologue of DC-SIGN that is expressed on macrophages, also binds both schistosome-soluble egg antigens and worm antigens in vitro. The generation of schistosome egg-induced pulmonary egg granulomas was not altered in SIGNR1-deficient mice. Following<jats:italic>S. mansoni<\/jats:italic>infection, the SIGNR1-deficient mice had an unaltered phenotype with an intact immunological response and no difference in pathology. In this study we demonstrate that although SIGNR1 recognizes<jats:italic>S. mansoni<\/jats:italic>antigens in vitro, this CLR is redundant during infection. This study highlights the finding that although there was binding of SIGNR1 to immunogenic factors produced in the<jats:italic>S. mansoni<\/jats:italic>life cycle, this recognition does not translate to a functional in vivo role for the PRR during infection.<\/jats:p>","DOI":"10.1128\/iai.00762-08","type":"journal-article","created":{"date-parts":[[2008,11,4]],"date-time":"2008-11-04T01:58:59Z","timestamp":1225763939000},"page":"399-404","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["The C-Type Lectin SIGNR1 Binds<i>Schistosoma mansoni<\/i>Antigens In Vitro, but SIGNR1-Deficient Mice Have Normal Responses during Schistosome Infection"],"prefix":"10.1128","volume":"77","author":[{"given":"Sean P.","family":"Saunders","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitriona M.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L.","family":"Barlow","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh E.","family":"Mangan","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Immunology, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N. 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