{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:22:57Z","timestamp":1789053777421,"version":"build-2803163510"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Bordetella pertussis<\/jats:italic>\n                    and\n                    <jats:italic>Bordetella parapertussis<\/jats:italic>\n                    are closely related endemic human pathogens which cause whooping cough, a disease that is reemerging in human populations. Despite how closely related these pathogens are, their coexistence and the limited efficacy of\n                    <jats:italic>B. pertussis<\/jats:italic>\n                    vaccines against\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    suggest a lack of cross-protective immunity between the two. We sought to address the ability of infection-induced immunity against one of these pathogens to protect against subsequent infection by the other using a mouse model of infection. Immunity induced by\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    infection protected against subsequent infections by either species. However, immunity induced by\n                    <jats:italic>B. pertussis<\/jats:italic>\n                    infection prevented subsequent\n                    <jats:italic>B. pertussis<\/jats:italic>\n                    infections but did not protect against\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    infections. The O antigen of\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    inhibited binding of antibodies to the bacterial surface and was required for\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    to colonize mice convalescent from\n                    <jats:italic>B. pertussis<\/jats:italic>\n                    infection. Thus, the O antigen of\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    confers asymmetrical cross-immunity between the causative agents of whooping cough. We propose that these findings warrant investigation of the relative role of\n                    <jats:italic>B. parapertussis<\/jats:italic>\n                    in the resurgence of whooping cough.\n                  <\/jats:p>","DOI":"10.1128\/iai.00763-07","type":"journal-article","created":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T20:26:09Z","timestamp":1187036769000},"page":"4972-4979","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["The O Antigen Enables\n                    <i>Bordetella parapertussis<\/i>\n                    To Avoid\n                    <i>Bordetella pertussis<\/i>\n                    -Induced Immunity"],"prefix":"10.1128","volume":"75","author":[{"given":"Daniel N.","family":"Wolfe","sequence":"first","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Goebel","sequence":"additional","affiliation":[{"name":"Huck Institute of Life Sciences, The Pennsylvania State University, 519 Wartik Lab, University Park, Pennsylvania 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottar N.","family":"Bjornstad","sequence":"additional","affiliation":[{"name":"Departments of Entomology and Biology, The Pennsylvania State University, 501 Agricultural Sciences and Industry Building, University Park, Pennsylvania 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Restif","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, Great Britain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric T.","family":"Harvill","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200007579X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1987.tb01936.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(99)90035-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.06.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.1.86-94.2003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3350-3358.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000177282.53500.77"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.8.977"},{"key":"e_1_3_2_10_2","first-page":"1","volume":"14","year":"1984","unstructured":"Cherry, J. 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