{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:14:16Z","timestamp":1787062456086,"version":"build-2736575974"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection results in the development of chronic gastritis, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are a major component of the gastric cellular infiltrate. To examine whether CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are important in initiating and maintaining\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -induced gastritis, mice deficient in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells (B6.BM1.GK 1.5 mice [GK 1.5 mice]) were infected with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . We found that as in normal mice,\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -specific antibodies, mostly of the immunoglobulin M isotype, developed in GK 1.5 mice but were unable to cure\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection. Further, while the stomachs of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected GK 1.5 mice were more heavily infiltrated with CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and B cells, mice deficient in both CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells developed mild inflammation comparable to the level observed for C57BL\/6 mice. These observations suggest that CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells may play an important role in regulating or suppressing gastric CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells which, in the absence of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, may mediate more-severe disease. These studies have revealed a potentially important role for CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the gastric disease resulting from\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1128\/iai.00779-07","type":"journal-article","created":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T21:08:18Z","timestamp":1195506498000},"page":"1289-1297","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["CD8\n                    <sup>+<\/sup>\n                    T Cells Are Associated with Severe Gastritis in\n                    <i>Helicobacter pylori<\/i>\n                    - Infected Mice in the Absence of CD4\n                    <sup>+<\/sup>\n                    T Cells"],"prefix":"10.1128","volume":"76","author":[{"given":"Mai Ping","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology and The Australian Bacterial Pathogenesis Program, University of Melbourne, Melbourne, Victoria 3010, Australia"},{"name":"Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Tissupath Pty. Ltd., Melbourne, Victoria 3122, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhan","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, Melbourne, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Lew","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, Melbourne, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Pearse","sequence":"additional","affiliation":[{"name":"CSL Limited, Melbourne, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odilia L. C.","family":"Wijburg","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and The Australian Bacterial Pathogenesis Program, University of Melbourne, Melbourne, Victoria 3010, Australia"},{"name":"Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Strugnell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and The Australian Bacterial Pathogenesis Program, University of Melbourne, Melbourne, Victoria 3010, Australia"},{"name":"Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171639"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916939509008018"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.09.011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70531-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.158.2.962","volume":"158","year":"1997","unstructured":"D'Elios, M. 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