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We investigated whether<jats:italic>Schistosoma mansoni<\/jats:italic>infection or injection of parasite eggs can modulate airway allergic inflammation in mice, examining the mechanisms of such regulation. We infected BALB\/c mice with 30<jats:italic>S. mansoni<\/jats:italic>cercariae or intraperitoneally injected 2,500 schistosome eggs, and experimental asthma was induced by ovalbumin (OVA). The number of eosinophils in bronchoalveolar lavage fluid was higher in the asthmatic group than in asthmatic mice infected with<jats:italic>S. mansoni<\/jats:italic>or treated with parasite eggs. Reduced Th2 cytokine production, characterized by lower levels of interleukin-4 (IL-4), IL-5, and immunoglobulin E, was observed in both<jats:italic>S. mansoni<\/jats:italic>-treated groups compared to the asthmatic group. There was a reduction in the number of inflammatory cells in lungs of<jats:italic>S. mansoni<\/jats:italic>-infected and egg-treated mice, demonstrating that both<jats:italic>S. mansoni<\/jats:italic>infection and the egg treatment modulated the lung inflammatory response to OVA. Only allergic animals that were treated with parasite eggs had increased numbers of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup>T cells and increased levels of IL-10 and decreased production of CCL2, CCL3, and CCL5 in the lungs compared to the asthmatic group. Neutralization of IL-10 receptor or depletion of CD25<jats:sup>+<\/jats:sup>T cells in vivo confirmed the critical role of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup>regulatory T cells in experimental asthma modulation independent of IL-10.<\/jats:p>","DOI":"10.1128\/iai.00783-07","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T00:44:51Z","timestamp":1222735491000},"page":"98-107","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":95,"title":["<i>Schistosoma mansoni<\/i>Antigens Modulate Experimental Allergic Asthma in a Murine Model: a Major Role for CD4<sup>+<\/sup>CD25<sup>+<\/sup>Foxp3<sup>+<\/sup>T Cells Independent of Interleukin-10"],"prefix":"10.1128","volume":"77","author":[{"given":"Lucila G. G.","family":"Paci\u0301fico","sequence":"first","affiliation":[{"name":"Departamento de Bioqui\u0301mica e Imunologia e Instituto para Investigac\u0327a\u0303o em Imunologia-Instituto Mile\u0302nio, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa\u0301bio A. V.","family":"Marinho","sequence":"additional","affiliation":[{"name":"Departamento de Bioqui\u0301mica e Imunologia e Instituto para Investigac\u0327a\u0303o em Imunologia-Instituto Mile\u0302nio, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina T.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Departamento de Bioqui\u0301mica e Imunologia e Instituto para Investigac\u0327a\u0303o em Imunologia-Instituto Mile\u0302nio, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"},{"name":"Laborato\u0301rio de Esquistossomose, CPqRR, FIOCRUZ, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele M.","family":"Barsante","sequence":"additional","affiliation":[{"name":"Departamento de Bioqui\u0301mica e Imunologia e Instituto para Investigac\u0327a\u0303o em Imunologia-Instituto Mile\u0302nio, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Pinho","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Policarpo A.","family":"Sales-Junior","sequence":"additional","affiliation":[{"name":"Hospital Santa Casa de Miserico\u0301rdia de Belo Horizonte, Nu\u0301cleo de Po\u0301s-Graduac\u0327a\u0303o e Pesquisa, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana S.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Servic\u0327o de Imunologia, Hospital Universita\u0301rio Professor Edgard Santos, Salvador, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ilma","family":"Arau\u0301jo","sequence":"additional","affiliation":[{"name":"Servic\u0327o de Imunologia, Hospital Universita\u0301rio Professor Edgard Santos, Salvador, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servic\u0327o de Imunologia, Hospital Universita\u0301rio Professor Edgard Santos, Salvador, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovanni D.","family":"Cassali","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro M.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqui\u0301mica e Imunologia e Instituto para Investigac\u0327a\u0303o em Imunologia-Instituto Mile\u0302nio, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqui\u0301mica e Imunologia e Instituto para Investigac\u0327a\u0303o em Imunologia-Instituto Mile\u0302nio, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2003.09.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.4.8616572"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000024433"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5374"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90044-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.3.7873190"},{"key":"e_1_3_2_8_2","first-page":"12","volume":"2","year":"2004","unstructured":"Chitsulo, L., P. 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