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Complement receptor 3 (CR3; also called CD11b\/CD18), a \u03b2<jats:sub>2<\/jats:sub>integrin on phagocytic cells, is one such receptor. Ligation of CR3 has been shown to inhibit the production of interleukin-12, the cytokine that is pivotal in establishing the cell-mediated response necessary to combat intracellular infection. Here we investigate the role that CR3 plays in the establishment and progression of cutaneous leishmaniaisis in vivo. Dermal lesions of wild-type BALB\/c mice are characteristically progressive and lead to extensive tissue necrosis coupled with elevated parasite burdens; CD11b-deficient BALB\/c mice, however, demonstrate an intermediate phenotype characterized by chronic lesions and a reduced incidence of tissue damage. Infection followed by a reinfection challenge indicates that both susceptible (BALB\/c) and resistant (C57BL\/6) mice, regardless of CD11b status, develop resistance to<jats:italic>L. major<\/jats:italic>. In addition, CD11b does not bias the T helper cytokine response to<jats:italic>L. major<\/jats:italic>infection. Our results further indicate that CD11b is not necessary for disease resolution in resistant mice; rather, this protein appears to play a minor role in susceptibility.<\/jats:p>","DOI":"10.1128\/iai.00802-08","type":"journal-article","created":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T01:48:31Z","timestamp":1253584111000},"page":"5668-5675","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Complement Receptor 3 Deficiency Influences Lesion Progression during<i>Leishmania major<\/i>Infection in BALB\/c Mice"],"prefix":"10.1128","volume":"77","author":[{"given":"Cristina R.","family":"Carter","sequence":"first","affiliation":[{"name":"Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Whitcomb","sequence":"additional","affiliation":[{"name":"Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami M.","family":"Mukbel","sequence":"additional","affiliation":[{"name":"Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"McDowell","sequence":"additional","affiliation":[{"name":"Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0706439"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53932-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00136-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.00969.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.6830-6834.2003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01505-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.52.2.135"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.1.324"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021908"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1636090"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.4217"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.02.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.09.067"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(03)00179-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80278-2"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2002.2418"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.1.25"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.336"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6105"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2001.00140.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)00299-9"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364056"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364042"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535079"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00853-05"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.5.2613"},{"key":"e_1_3_2_28_2","first-page":"100","volume":"10","year":"2008","unstructured":"Gueirard, P., A. 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