{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:11:37Z","timestamp":1753881097828,"version":"3.41.2"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Victorian Operational Infrastructure Support Program"},{"name":"Juvenile Diabetes Research Foundation (JDRF) International","award":["DK062882"],"award-info":[{"award-number":["DK062882"]}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Mycoplasmas are bacterial pathogens of a range of animals, including humans, and are a common cause of respiratory disease. However, the host genetic factors that affect resistance to infection or regulate the resulting pulmonary inflammation are not well defined. We and others have previously demonstrated that nonobese diabetic (NOD) mice can be used to investigate disease loci that affect bacterial infection and autoimmune diabetes. Here we show that NOD mice are more susceptible than C57BL\/6 (B6) mice to infection with\n            <jats:named-content content-type=\"genus-species\">Mycoplasma pulmonis<\/jats:named-content>\n            , a natural model of pulmonary mycoplasmosis. The lungs of infected NOD mice had higher loads of\n            <jats:named-content content-type=\"genus-species\">M. pulmonis<\/jats:named-content>\n            and more severe inflammatory lesions. Moreover, congenic NOD mice that harbored different B6-derived chromosomal intervals enabled identification and localization of a new mycoplasmosis locus, termed\n            <jats:italic>Mpr2<\/jats:italic>\n            , on chromosome 13. These congenic NOD mice demonstrated that the B6 allele for\n            <jats:italic>Mpr2<\/jats:italic>\n            reduced the severity of pulmonary inflammation caused by infection with\n            <jats:named-content content-type=\"genus-species\">M. pulmonis<\/jats:named-content>\n            and that this was associated with altered cytokine and chemokine concentrations in the infected lungs.\n            <jats:italic>Mpr2<\/jats:italic>\n            also colocalizes to the same genomic interval as\n            <jats:italic>Listr2<\/jats:italic>\n            and\n            <jats:italic>Idd14<\/jats:italic>\n            , genetic loci linked to listeriosis resistance and autoimmune diabetes susceptibility, respectively, suggesting that allelic variation within these loci may affect the development of both infectious and autoimmune disease.\n          <\/jats:p>","DOI":"10.1128\/iai.00812-17","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T13:39:23Z","timestamp":1513690763000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune-Disease-Prone NOD Mice Help To Reveal a New Genetic Locus for Reducing Pulmonary Disease Caused by Mycoplasma pulmonis"],"prefix":"10.1128","volume":"86","author":[{"given":"Nadeeka K.","family":"Wawegama","sequence":"first","affiliation":[{"name":"Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria and Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip F.","family":"Markham","sequence":"additional","affiliation":[{"name":"Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria and Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen M.","family":"Elso","sequence":"additional","affiliation":[{"name":"St. Vincent's Institute and Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kanci","sequence":"additional","affiliation":[{"name":"Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria and Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc S.","family":"Marenda","sequence":"additional","affiliation":[{"name":"Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria and Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-2469","authenticated-orcid":false,"given":"Glenn F.","family":"Browning","sequence":"additional","affiliation":[{"name":"Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria and Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2294-315X","authenticated-orcid":false,"given":"Thomas C.","family":"Brodnicki","sequence":"additional","affiliation":[{"name":"St. Vincent's Institute and Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"675","article-title":"Murine chronic respiratory disease. 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