{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:53:30Z","timestamp":1790380410989,"version":"4.1.0"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"HHS | Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"<jats:p>Human genital<jats:italic>Chlamydia<\/jats:italic>infection is a major public health concern due to the serious reproductive system complications.<jats:italic>Chlamydia<\/jats:italic>binds several receptor tyrosine kinases (RTKs) on host cells, including the epidermal growth factor receptor (EGFR), and activates cellular signaling cascades for host invasion, cytoskeletal remodeling, optimal inclusion development, and induction of pathogenic epithelial-mesenchyme transition (EMT).<jats:italic>Chlamydia<\/jats:italic>also upregulates transforming growth factor beta (TGF-\u03b2) expression, whose signaling pathway synergizes with the EGFR cascade, but its role in infectivity, inclusions, and EMT induction is unknown.<\/jats:p>","DOI":"10.1128\/iai.00819-19","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T09:32:09Z","timestamp":1579685529000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Epidermal Growth Factor Receptor and Transforming Growth Factor \u03b2 Signaling Pathways Cooperate To Mediate<i>Chlamydia<\/i>Pathogenesis"],"prefix":"10.1128","volume":"88","author":[{"given":"Joseph U.","family":"Igietseme","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"},{"name":"Morehouse School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Partin","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenas","family":"George","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Omosun","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"},{"name":"Morehouse School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahaliah","family":"Joseph","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Ellerson","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis O.","family":"Eko","sequence":"additional","affiliation":[{"name":"Morehouse School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Pohl","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu","family":"Bandea","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Black","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Sexually transmitted disease surveillance 2016","author":"CDC","year":"2017","unstructured":"CDC. 2017. Sexually transmitted disease surveillance 2016. CDC, Atlanta, GA."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003077"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aau9894"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7030860"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2015.08.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145198"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw569"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-014-0277-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003325"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12549"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.12.5301-5308.1997"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002285"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.11.034"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0797-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1158\/0008-5472.338.65.1","article-title":"Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer","volume":"65","author":"Lo H-W","year":"2005","unstructured":"Lo H-W, Xia W, Wei Y, Ali-Seyed M, Huang S-F, Hung M-C. 2005. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res 65:338\u2013348.","journal-title":"Cancer Res"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0368"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aas9473"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2016_10"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12162"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0136"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0234"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1558"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.239"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3980"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070353"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410100417"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2649"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210915"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000021"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4142"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.186"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.4.1406-1414.1993"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000651"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020045"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08827"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.05.018"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21263"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13922"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00082"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(96)81385-4"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3843-4"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.12.4465-4472.1991"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.169599"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00585-17"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81460-9"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.12.009"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9765"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7304"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.12.006"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/804236"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5070063"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021907"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0112-6"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4643"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.01.013"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.03.125"},{"key":"e_1_3_2_58_2","first-page":"549","article-title":"Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells","volume":"21","author":"Yim EK","year":"2009","unstructured":"Yim EK, Tong S, Ho EM, Bae JH, Um SJ, Park JS. 2009. Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. Oncol Rep 21:549\u2013557.","journal-title":"Oncol Rep"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8262"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1086\/605411"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00106-15"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.3951-3960.2004"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.1.65"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-040005"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0802fje"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010300107"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00819-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00819-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T09:18:53Z","timestamp":1665566333000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00819-19"}},"subtitle":[],"editor":[{"given":"Craig R.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,3,23]]}},"alternative-id":["10.1128\/IAI.00819-19"],"URL":"https:\/\/doi.org\/10.1128\/iai.00819-19","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]},"assertion":[{"value":"2019-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00819-19"}}