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However, it is not understood how catheters induce these changes, how these changes act to promote infection, or whether they may have any protective benefit. In the present study, we examined how catheter-associated inflammation impacts infection by\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterococcus faecalis<\/jats:named-content>\n                    , a leading cause of catheter-associated urinary tract infection (CAUTI), a source of significant societal and clinical challenges. Using a recently optimized murine model of foreign body-associated UTI, we found that the implanted catheter itself was the primary inducer of inflammation. In the absence of the silicone tubing implant,\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. faecalis<\/jats:named-content>\n                    induced only minimal inflammation and was rapidly cleared from the bladder. The catheter-induced inflammation was only minimally altered by subsequent enterococcal infection and was not suppressed by inhibitors of the neurogenic pathway and only partially by dexamethasone. Despite the robust inflammatory response induced by urinary implantation,\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. faecalis<\/jats:named-content>\n                    produced biofilm and high bladder titers in these animals. Induction of inflammation in the absence of an implanted catheter failed to promote infection, suggesting that the presence of the catheter itself is essential for\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. faecalis<\/jats:named-content>\n                    persistence in the bladder. Immunosuppression prior to urinary catheterization enhanced\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. faecalis<\/jats:named-content>\n                    colonization, suggesting that implant-mediated inflammation contributes to the control of enterococcal infection. Thus, this study underscores the need for novel strategies against CAUTIs that seek to reduce the deleterious effects of implant-mediated inflammation on bladder homeostasis while maintaining an active immune response that effectively limits bacterial invaders.\n                  <\/jats:p>","DOI":"10.1128\/iai.00856-12","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T02:52:36Z","timestamp":1352256756000},"page":"329-339","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":113,"title":["Enterococcus faecalis Overcomes Foreign Body-Mediated Inflammation To Establish Urinary Tract Infections"],"prefix":"10.1128","volume":"81","author":[{"given":"Pascale S.","family":"Guiton","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, Saint Louis, Missouri, USA"},{"name":"Center for Women's Infectious Disease Research, Washington University in St. Louis, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hannan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University in St. Louis, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, Saint Louis, Missouri, USA"},{"name":"Center for Women's Infectious Disease Research, Washington University in St. Louis, Saint Louis, Missouri, USA"},{"name":"Department of Pathology and Immunology, Washington University in St. Louis, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Caparon","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, Saint Louis, Missouri, USA"},{"name":"Center for Women's Infectious Disease Research, Washington University in St. Louis, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Hultgren","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, Saint Louis, Missouri, USA"},{"name":"Center for Women's Infectious Disease Research, Washington University in St. Louis, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700055533"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4065\/74.2.131"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00359-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196804252781719"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008073030605"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(21)00262-7"},{"key":"e_1_3_3_8_2","first-page":"325","article-title":"Changes in the urinary bladder caused by short-term permanent catheter insertion","volume":"147","author":"Peychl L","year":"2008","unstructured":"PeychlLZaludR. 2008. 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