{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:14:37Z","timestamp":1792102477697,"version":"4.4.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"crossref","award":["Internal funding"],"award-info":[{"award-number":["Internal funding"]}],"id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"crossref","award":["Internal funding"],"award-info":[{"award-number":["Internal funding"]}],"id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL105427"],"award-info":[{"award-number":["HL105427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL007317"],"award-info":[{"award-number":["T32 HL007317"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["CFF\/FRIZZE15R0"],"award-info":[{"award-number":["CFF\/FRIZZE15R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010559","name":"UPMC | Children's Hospital of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections, and inflammation, which, in turn, cause chronic lung disease and respiratory failure. Recently, rates of nontuberculous mycobacterial (NTM) infections in CF patients have been increasing. Of particular relevance is infection with\n            <jats:named-content content-type=\"genus-species\">Mycobacterium abscessus<\/jats:named-content>\n            , which causes a serious, life-threatening disease and constitutes one of the most antibiotic-resistant NTM species. Interestingly, an increased prevalence of NTM infections is associated with worsening lung function in CF patients who are also coinfected with\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            . We established a new mouse model to investigate the relationship between\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n            pulmonary infections. In this model, animals exposed to\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            and coinfected with\n            <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n            exhibited increased lung inflammation and decreased mycobacterial burden compared with those of mice infected with\n            <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n            alone. This increased control of\n            <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n            infection in coinfected mice was mucus independent but dependent on both transcription factors T-box 21 (Tbx21) and retinoic acid receptor (RAR)-related orphan receptor gamma t (ROR\u03b3-t), master regulators of type 1 and type 17 immune responses, respectively. These results implicate a role for both type 1 and type 17 responses in\n            <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n            control in\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            -coinfected lungs. Our results demonstrate that\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            , an organism found commonly in CF patients with NTM infection, can worsen pulmonary inflammation and impact\n            <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n            control in a mouse model.\n          <\/jats:p>","DOI":"10.1128\/iai.00859-17","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T13:39:40Z","timestamp":1513690780000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice"],"prefix":"10.1128","volume":"86","author":[{"given":"Leticia","family":"Monin","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA"},{"name":"Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shail","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1170-4890","authenticated-orcid":false,"given":"Waleed","family":"Elsegeiny","sequence":"additional","affiliation":[{"name":"Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Gopal","sequence":"additional","affiliation":[{"name":"Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"McAleer","sequence":"additional","affiliation":[{"name":"Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D.","family":"Oury","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Kolls","sequence":"additional","affiliation":[{"name":"Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabaana 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