{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:56:10Z","timestamp":1715558170092},"reference-count":16,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In this study, we report the use of peptide-major histocompatibility complex tetramer technology to study the interactions that occur between<jats:italic>Staphylococcus aureus<\/jats:italic>proteins and human leukocytes. We demonstrated that this technology can be used to study the activity of superantigens such as toxic shock syndrome toxin 1 and also found that despite similarities to known proteins (i.e., major histocompatibility complex [MHC] class II molecules and superantigens), the<jats:italic>S. aureus<\/jats:italic>Eap protein does not block MHC-T-cell receptor interactions and is not a superantigen. Instead, it has nonspecific cross-linking activity that is dependent upon having at least two of its six 110-amino-acid repeats.<\/jats:p>","DOI":"10.1128\/iai.00875-07","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T00:34:25Z","timestamp":1192494865000},"page":"5711-5715","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Use of Peptide-Major Histocompatibility Complex Tetramer Technology To Study Interactions between<i>Staphylococcus aureus<\/i>Proteins and Human Cells"],"prefix":"10.1128","volume":"75","author":[{"given":"Ruth C.","family":"Massey","sequence":"first","affiliation":[{"name":"Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Scriba","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric L.","family":"Brown","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health, 1200 Herman Pressler, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney E.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew K.","family":"Sewell","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Immunology, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.94"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.8.2917-2919.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm728"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1160\/TH05-05-0306","volume":"94","year":"2005","unstructured":"Chavakis, T., K. Wiechmann, K. T. Preissner, and M. Herrmann. 2005. Staphylococcus aureus interactions with the endothelium: the role of bacterial \u201csecretable expanded repertoire adhesive molecules\u201d (SERAM) in disturbing host defense systems. Thromb. Haemost.94:278-285.","journal-title":"Thromb. 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Current and emerging serious Gram-positive infections. Clin. Microbiol. Infect.3:22-28.","journal-title":"Clin. Microbiol. Infect."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6334"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00875-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00875-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T12:12:13Z","timestamp":1684066333000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00875-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1128\/IAI.00875-07"],"URL":"https:\/\/doi.org\/10.1128\/iai.00875-07","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"2007-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}