{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:36:42Z","timestamp":1776375402130,"version":"3.51.2"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Marfan syndrome is an autosomal dominant disease characterized by aneurysm and dilatation of the aortic root, tall stature, and ectopia lentis. These manifestations reflect excessive signaling of transforming growth factor beta (TGF-\u03b2). Moreover, cases are frequently associated with severe periodontitis, which is a chronic inflammation of the gingiva, periodontal ligament, and alveolar bone. Recently, angiotensin II receptor blockers (ARBs) were discovered to be an effective drug class that can prevent aortic aneurysm and dilation in Marfan syndrome by inhibiting TGF-\u03b2 signaling. To investigate the effect of ARB on the progression of periodontitis, the application of a potent ARB, telmisartan, was examined in a mouse model of Marfan syndrome (Mg\u0394). Six-week-old male heterozygous Mg\u0394 and wild-type mice were challenged with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Porphyromonas gingivalis<\/jats:named-content>\n            , which causes chronic periodontitis, with and without telmisartan application. After infection, alveolar bone resorption was measured by micro-computed tomography (\u03bcCT), and inflammatory cytokine levels were examined. Infection of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Porphyromonas gingivalis<\/jats:named-content>\n            induced alveolar bone resorption in both Mg\u0394 and wild-type mice. The amount of resorption was significantly larger in the former than the latter. Immunoarray and enzyme-linked immunosorbent assay (ELISA) analyses demonstrated that interleukin-17 (IL-17) and tumor necrosis factor alpha (TNF-\u03b1) levels were significantly higher in infected Mg\u0394 mice than infected wild-type mice. Telmisartan treatment significantly suppressed the alveolar bone resorption of infected Mg\u0394 mice. Telmisartan also significantly decreased levels of TGF-\u03b2, IL-17, and TNF-\u03b1 in infected Mg\u0394 mice to levels seen in infected wild-type mice. This study suggests that ARB can prevent the severe periodontitis frequently seen in Marfan syndrome.\n          <\/jats:p>","DOI":"10.1128\/iai.00886-12","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T04:25:46Z","timestamp":1351743946000},"page":"182-188","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Angiotensin II Receptor Blocker on Experimental Periodontitis in a Mouse Model of Marfan Syndrome"],"prefix":"10.1128","volume":"81","author":[{"given":"Naoto","family":"Suda","sequence":"first","affiliation":[{"name":"Division of Orthodontics, Department of Human Development &amp; Fostering, Meikai University School of Dentistry, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial\/Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganjargal","family":"Ganburged","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Orthodontics, Dental School, Health Science University of Mongolia, Ulaanbaatar, Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00423.x"},{"key":"e_1_3_2_3_2","first-page":"5","article-title":"New considerations in the prevalence of periodontal disease","volume":"2","author":"Fox CH","year":"1992","unstructured":"FoxCH. 1992. New considerations in the prevalence of periodontal disease. Curr. Opin. Dent. 2:5\u201311.","journal-title":"Curr. Opin. Dent."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.7.676"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01545.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2001.22250104.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb02314.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/352279a0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67789-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900004200"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706585"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1116"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0528-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.7.823"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.121430"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.03.051"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000123072.34629.57"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328313e547"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.11.139"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-218"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00965.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.5864-5868.2000"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000082462.26258.FE"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/159874"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.06.012"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060320"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1013"},{"key":"e_1_3_2_30_2","unstructured":"PageRCSchroederHE. 1982. Periodontitis in man and other animals: a comparative review p 5\u201341. Karger Medical and Scientific Publishers Basel Switzerland."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb00999.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302x.2000.150105.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(94)35135-X"},{"key":"e_1_3_2_34_2","unstructured":"PageRCSchroederHE. 1982. Periodontitis in man and other animals: a comparative review p 222\u2013283. Karger Medical and Scientific Publishers Basel Switzerland."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260601.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1282"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(98)01363-8"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62961-6"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090015"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.2.275"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22326"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917020-00015"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192152"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.48.637"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4471-4479.2004"},{"key":"e_1_3_2_46_2","first-page":"45","article-title":"Comparative evaluation of IFN\u03b3, IL4 and IL17 cytokines in healthy gingiva and moderate to advanced chronic periodontitis","volume":"7","author":"Behfarnia P","year":"2010","unstructured":"BehfarniaPBirangRAndalibARAsadiS. 2010. Comparative evaluation of IFN\u03b3, IL4 and IL17 cytokines in healthy gingiva and moderate to advanced chronic periodontitis. Dent. Res. J. (Isfahan) 7:45\u201350.","journal-title":"Dent. Res. J. (Isfahan)"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510378423"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00886-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00886-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:23:07Z","timestamp":1646482987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00886-12"}},"subtitle":[],"editor":[{"given":"J. B.","family":"Bliska","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1128\/IAI.00886-12"],"URL":"https:\/\/doi.org\/10.1128\/iai.00886-12","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2012-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}