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We previously showed that<jats:named-content content-type=\"genus-species\">Rickettsia australis<\/jats:named-content>activates ASC inflammasome in macrophages. In the present study, host susceptibility of ASC inflammasome-deficient mice to<jats:named-content content-type=\"genus-species\">R. australis<\/jats:named-content>was significantly greater than that of C57BL\/6 (B6) controls and was accompanied by increased rickettsial loads in various organs. 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