{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:01:21Z","timestamp":1787162481253,"version":"build-2736575974"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A strain of\n                    <jats:italic>Mycobacterium bovis<\/jats:italic>\n                    BCG that secretes high levels of functional murine monocyte chemotactic protein 3 (BCG\n                    <jats:sub>MCP-3<\/jats:sub>\n                    ) was developed. Mice vaccinated with BCG\n                    <jats:sub>MCP-3<\/jats:sub>\n                    displayed increased lymphocyte migration in vivo and augmented antigen-specific T-cell responses compared to mice vaccinated with BCG alone. The level of protection afforded by BCG\n                    <jats:sub>MCP-3<\/jats:sub>\n                    was equivalent to that with control BCG; however, immunodeficient mice infected with BCG\n                    <jats:sub>MCP-3<\/jats:sub>\n                    survived significantly longer than mice infected with the control BCG strain. Therefore, BCG\n                    <jats:sub>MCP-3<\/jats:sub>\n                    may be a safer alternative than conventional BCG for vaccination of immunocompromised individuals.\n                  <\/jats:p>","DOI":"10.1128\/iai.00897-06","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T18:51:25Z","timestamp":1166640685000},"page":"523-526","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Secretion of Functional Monocyte Chemotactic Protein 3 by Recombinant\n                    <i>Mycobacterium bovis<\/i>\n                    BCG Attenuates Vaccine Virulence and Maintains Protective Efficacy against\n                    <i>M. tuberculosis<\/i>\n                    Infection"],"prefix":"10.1128","volume":"75","author":[{"given":"Anthony A.","family":"Ryan","sequence":"first","affiliation":[{"name":"Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Spratt","sequence":"additional","affiliation":[{"name":"Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick J.","family":"Britton","sequence":"additional","affiliation":[{"name":"Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042, Australia"},{"name":"Discipline of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Triccas","sequence":"additional","affiliation":[{"name":"Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042, Australia"},{"name":"Discipline of Infectious Diseases and Immunology, University of Sydney, Camperdown, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830241249"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1211"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1776"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0086"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/6995"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.4049\/jimmunol.148.4.1280","volume":"148","year":"1992","unstructured":"Bottazzi, B., S. 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