{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:46:26Z","timestamp":1790916386921,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"JSPS KAKENHI","award":["18H03010"],"award-info":[{"award-number":["18H03010"]}]},{"name":"JSPS KAKENHI","award":["18K09831"],"award-info":[{"award-number":["18K09831"]}]},{"name":"JSPS KAKENHI","award":["18K17254"],"award-info":[{"award-number":["18K17254"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,6,22]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Streptococcus mutans<\/jats:named-content>\n            , a major pathogen of dental caries, is regarded as a causative agent of infective endocarditis (IE), which mainly occurs in patients with underlying heart disease. However, it remains unknown whether severe dental caries that extend to pulp space represent a possible route of infection. In the present study, we evaluated the virulence of\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            for IE development using rats with concurrent severe dental caries and heart valve injury.\n          <\/jats:p>","DOI":"10.1128\/iai.00897-19","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T15:06:27Z","timestamp":1587395187000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["Contribution of Severe Dental Caries Induced by Streptococcus mutans to the Pathogenicity of Infective Endocarditis"],"prefix":"10.1128","volume":"88","author":[{"given":"Ryota","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saaya","family":"Matayoshi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Otsugu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Teramoto","sequence":"additional","affiliation":[{"name":"OSU Co., Ltd., Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15266-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.901"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4800845"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.758524"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0046"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2010.09.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60031-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511405323"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159613"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0549"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis021"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw249"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1996.tb00356.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016433"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871529x10909040240"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-013-0235-8"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2017.1296916"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-019-0867-1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00742"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02164-14"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.53.189"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00067-7"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720010501"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112001953"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139315"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1977.03630210045014"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.046"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.152.9.1869"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02851-5"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-97"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.49"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.43"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-017-0574-9"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02343-06"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46609-0"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.04.001"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323376"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1962.0184"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.07.021"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)76589-0"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1012518"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00332"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00897-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00897-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:49:24Z","timestamp":1646480964000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00897-19"}},"subtitle":[],"editor":[{"given":"Nancy E.","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,6,22]]}},"alternative-id":["10.1128\/IAI.00897-19"],"URL":"https:\/\/doi.org\/10.1128\/iai.00897-19","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]},"assertion":[{"value":"2019-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00897-19"}}