{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:26:55Z","timestamp":1767961615829,"version":"3.49.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            MarA, an AraC\/XylS transcriptional regulator in\n            <jats:italic>Escherichia coli<\/jats:italic>\n            , affects drug susceptibility and virulence. Two MarA-like proteins have been found in\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            : MarA47 and MarA48. Deletion or overexpression of these proteins in the attenuated KIM 1001 \u0394\n            <jats:italic>pgm<\/jats:italic>\n            strain led to a change in multidrug susceptibility (including susceptibility to clinically relevant drugs). Additionally, lung colonization by the\n            <jats:italic>marA47<\/jats:italic>\n            or\n            <jats:italic>marA48<\/jats:italic>\n            deletion mutant was decreased about 10-fold in a pneumonic plague mouse model. Complementation of the deletions by replacing the deleted genes on the chromosome restored wild-type characteristics. These findings show that two MarA homologs in\n            <jats:italic>Y. pestis<\/jats:italic>\n            affect antibiotic susceptibility and virulence.\n          <\/jats:p>","DOI":"10.1128\/iai.00904-09","type":"journal-article","created":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T00:59:02Z","timestamp":1256000342000},"page":"364-371","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Effect of MarA-Like Proteins on Antibiotic Resistance and Virulence in\n            <i>Yersinia pestis<\/i>"],"prefix":"10.1128","volume":"78","author":[{"given":"Ida M.","family":"Lister","sequence":"first","affiliation":[{"name":"Center for Adaptation Genetics and Drug Resistance"},{"name":"Departments of Molecular Biology and Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Mecsas","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart B.","family":"Levy","sequence":"additional","affiliation":[{"name":"Center for Adaptation Genetics and Drug Resistance"},{"name":"Departments of Molecular Biology and Microbiology"},{"name":"Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2067"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.12.3467-3474.2000"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.13.3794-3801.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2006\/000604-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603456103"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.5.1484-1492.1993"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05928.x"},{"key":"e_1_3_2_9_2","first-page":"99","volume":"53","year":"1968","unstructured":"Finegold, M. 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