{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:47:27Z","timestamp":1783594047560,"version":"3.55.0"},"reference-count":61,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI121989"],"award-info":[{"award-number":["R01AI121989"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI047997"],"award-info":[{"award-number":["R01AI047997"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"<jats:p>\n            Sexually transmitted\n            <jats:italic>Chlamydia<\/jats:italic>\n            , which can cause fibrotic pathology in women\u2019s genital tracts, is also frequently detected in the gastrointestinal tract. However, the medical significance of the gastrointestinal\n            <jats:italic>Chlamydia<\/jats:italic>\n            remains unclear. A murine\n            <jats:italic>Chlamydia<\/jats:italic>\n            readily spreads from the mouse genital tract to the gastrointestinal tract while inducing oviduct fibrotic blockage or hydrosalpinx. We previously proposed a two-hit model in which the mouse gastrointestinal\n            <jats:italic>Chlamydia<\/jats:italic>\n            might induce the second hit to promote genital tract pathology, and we are now providing experimental evidence for testing the hypothesis.\n          <\/jats:p>","DOI":"10.1128\/iai.00905-19","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T10:25:17Z","timestamp":1580120717000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Gastrointestinal Coinfection Promotes Chlamydial Pathogenicity in the Genital Tract"],"prefix":"10.1128","volume":"88","author":[{"given":"Qi","family":"Tian","sequence":"first","affiliation":[{"name":"The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengzi","family":"Zhou","sequence":"additional","affiliation":[{"name":"The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Wang","sequence":"additional","affiliation":[{"name":"The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al-Mutassim Hani","family":"Abu-Khdeir","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Huo","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schenken","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xue","sequence":"additional","affiliation":[{"name":"The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Sexually transmitted disease surveillance, 2016","author":"Centers for Disease Control and Prevention","year":"2017","unstructured":"Centers for Disease Control and Prevention. 2017. 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