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When these cultures were harvested and injected intranasally into mice, no bacteria could be recovered from the lungs for about 3 weeks, but after that evidence of regrowth was observed. Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis.\n          <\/jats:p>","DOI":"10.1128\/iai.00918-06","type":"journal-article","created":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T01:36:04Z","timestamp":1170725764000},"page":"2621-2625","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["In Vivo Adaptation of the Wayne Model of Latent Tuberculosis"],"prefix":"10.1128","volume":"75","author":[{"given":"Lisa","family":"Woolhiser","sequence":"first","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Henao","family":"Tamayo","sequence":"additional","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Gruppo","sequence":"additional","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Belisle","sequence":"additional","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Basaraba","sequence":"additional","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Orme","sequence":"additional","affiliation":[{"name":"Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02779.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/11309"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4195-4201.2001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)02403-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02238-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.570-575.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2003.12.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.4.2533-2540.2005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.03.002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2294-2301.2005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/82139"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/35021074"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1252"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2003.12.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-829504"},{"key":"e_1_3_2_17_2","first-page":"589","volume":"5","year":"2001","unstructured":"Orme, I. 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