{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:55:35Z","timestamp":1777992935437,"version":"3.51.4"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Both<jats:italic>Plasmodium<\/jats:italic>and<jats:italic>Babesia<\/jats:italic>species are intraerythrocytic protozoans that infect a wide range of hosts, including humans, and they elicit similar inflammatory responses and clinical manifestations that differ markedly in severity. We recently reported that a rhesus macaque that was chronically infected with<jats:italic>Babesia microti<\/jats:italic>was able to control infection with<jats:italic>Plasmodium cynomolgi<\/jats:italic>(a parasite of macaques with characteristics very similar to those of<jats:italic>Plasmodium vivax<\/jats:italic>) better than nai\u0308ve monkeys. To confirm this and to investigate the underlying immunopathology, six nai\u0308ve rhesus monkeys were infected with<jats:italic>B. microti<\/jats:italic>. After 24 days, four of these monkeys and four nai\u0308ve rhesus monkeys were challenged with<jats:italic>P. cynomolgi<\/jats:italic>blood-stage parasites.<jats:italic>B. microti<\/jats:italic>persisted at low levels in all monkeys, and the clinical parameters were comparable to those of noninfected controls. There was a significant decrease in<jats:italic>P. cynomolgi<\/jats:italic>parasitemia in animals coinfected with<jats:italic>B. microti<\/jats:italic>compared to the parasitemia in animals infected with<jats:italic>P. cynomolgi<\/jats:italic>alone. This decrease in<jats:italic>P. cynomolgi<\/jats:italic>parasitemia correlated with increases in the levels of proinflammatory monocytes at the time of<jats:italic>P. cynomolgi<\/jats:italic>infection and with higher C-reactive protein (CRP) serum levels 1 week after malaria infection. Therefore, we conclude that ongoing infection with<jats:italic>B. microti<\/jats:italic>parasites leads to suppression of malaria infection.<\/jats:p>","DOI":"10.1128\/iai.00921-09","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T02:10:40Z","timestamp":1262657440000},"page":"1032-1039","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Suppression of<i>Plasmodium cynomolgi<\/i>in Rhesus Macaques by Coinfection with<i>Babesia microti<\/i>"],"prefix":"10.1128","volume":"78","author":[{"given":"Leonie M.","family":"van Duivenvoorde","sequence":"first","affiliation":[{"name":"Department of Parasitology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie","family":"Voorberg-van der Wel","sequence":"additional","affiliation":[{"name":"Department of Parasitology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"van der Werff","sequence":"additional","affiliation":[{"name":"Department of Parasitology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerco","family":"Braskamp","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Biomedical Primate Research Centre, Rijswijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond J.","family":"Remarque","sequence":"additional","affiliation":[{"name":"Department of Parasitology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanela","family":"Kondova","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Biomedical Primate Research Centre, Rijswijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens H. M.","family":"Kocken","sequence":"additional","affiliation":[{"name":"Department of Parasitology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan W.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Parasitology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00834.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80036-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-006-7928-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3536"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00569-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00279.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200100734X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1961.10.673"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047387"},{"key":"e_1_3_2_11_2","first-page":"337","volume":"43","year":"1970","unstructured":"Cox, F. E., and S. A. Turner. 1970. Antigenic relationships between the malaria parasites and piroplasms of mice as determined by the fluorescent-antibody technique. Bull. World Health Organ.43:337-340.","journal-title":"Bull. World Health Organ."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1970.11686678"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/524888"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8124"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.1.373.373"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1998.11813307"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.06.006"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1164"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/319742"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.451"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4143-4148.1999"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1012.040293"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2000.020004281.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00137-5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00576-08"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.09.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.431"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530450047031"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.08.004"},{"key":"e_1_3_2_30_2","first-page":"628","volume":"41","year":"2000","unstructured":"Matsui, T., R. Inoue, K. Kajimoto, A. Tamekane, A. Okamura, Y. Katayama, M. Shimoyama, K. Chihara, A. Saito-Ito, and M. Tsuji. 2000. First documentation of transfusion-associated babesiosis in Japan. Rinsho Ketsueki41:628-634. (In Japanese.)","journal-title":"Rinsho Ketsueki"},{"key":"e_1_3_2_31_2","first-page":"335","volume":"29","year":"1980","unstructured":"Matsumoto, K., H. Akagi, T. Ochiai, K. Hagino, K. Sekita, Y. Kawasaki, M. A. Matin, and T. Furuya. 1980. Comparative blood values of Macaca mulatta and Macaca fascicularis. Jikken Dobutsu29:335-340.","journal-title":"Jikken Dobutsu"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.64.97"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(99)00007-7"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.4.1215.bloodjournal8841215"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00653.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.7.2527.2527"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1500-1506.1998"},{"key":"e_1_3_2_38_2","first-page":"503","volume":"92","year":"1998","unstructured":"Reyers, F., A. L. Leisewitz, R. G. Lobetti, R. J. Milner, L. S. Jacobson, and M. van Zyl. 1998. Canine babesiosis in South Africa: more than one disease. Does this serve as a model for falciparum malaria? Ann. Trop. Med. Parasitol.92:503-511.","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90298-5"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1961.10.679"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.58.335"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-005-1434-3"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.07.003"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15836-4"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03342"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.78.643"},{"key":"e_1_3_2_47_2","first-page":"914","volume":"10","year":"1993","unstructured":"Waters, A. P., D. G. Higgins, and T. F. McCutchan. 1993. Evolutionary relatedness of some primate models of Plasmodium. Mol. Biol. Evol.10:914-923.","journal-title":"Mol. Biol. Evol."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01978.x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00348580","volume":"41","year":"1973","unstructured":"Wright, I. G. 1973. Plasma kallikrein levels in acute Babesia argentina infections in splenectomised and intact calves. Z. Parasitenkd.41:269-280.","journal-title":"Z. Parasitenkd."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)33799-8"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0806510"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00921-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00921-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:51:59Z","timestamp":1711111919000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00921-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1128\/IAI.00921-09"],"URL":"https:\/\/doi.org\/10.1128\/iai.00921-09","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"2009-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}