{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:41:48Z","timestamp":1789951308274,"version":"4.0.1"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Klebsiella pneumoniae magA<\/jats:italic>\n            (for mucoviscosity-associated gene A) is linked to the pathogenesis of primary pyogenic liver abscess, but the underlying mechanism by which\n            <jats:italic>magA<\/jats:italic>\n            increases pathogenicity is not well elucidated. In this study, we investigated the role of the capsular polysaccharides (CPS) in the pathogenesis of\n            <jats:italic>magA<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            by comparing host immunity to\n            <jats:italic>magA<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            and a \u0394\n            <jats:italic>magA<\/jats:italic>\n            mutant. We found that Toll-like receptor 4 recognition by\n            <jats:italic>magA<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            was hampered by the mucoviscosity of the\n            <jats:italic>magA<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            CPS. Interestingly, monoclonal antibodies (MAbs) against\n            <jats:italic>magA<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            CPS recognized all of the K1 strains tested but not the \u0394\n            <jats:italic>magA<\/jats:italic>\n            and non-K1 strains. Moreover, the anti-CPS MAbs protected mice from\n            <jats:italic>magA<\/jats:italic>\n            <jats:sup>+<\/jats:sup>\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            -induced liver abscess formation and lethality. This indicates that the K1 epitope is a promising target for vaccine development, and anti-CPS MAbs has great potential to protect host from K1 strain-induced mortality and morbidity in diabetic and other immunocompromised patients in the future.\n          <\/jats:p>","DOI":"10.1128\/iai.00931-08","type":"journal-article","created":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T01:55:54Z","timestamp":1226973354000},"page":"615-621","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Humoral Immunity against Capsule Polysaccharide Protects the Host from\n            <i>magA<\/i>\n            <sup>+<\/sup>\n            <i>Klebsiella pneumoniae<\/i>\n            -Induced Lethal Disease by Evading Toll-Like Receptor 4 Signaling"],"prefix":"10.1128","volume":"77","author":[{"given":"Ming-Fang","family":"Wu","sequence":"first","affiliation":[{"name":"Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ya","family":"Yang","sequence":"additional","affiliation":[{"name":"Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Lung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Town","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology"},{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsiung","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Shen","family":"Hu","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Taipei City Hospital Heping Branch, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teh-Ying","family":"Chou","sequence":"additional","affiliation":[{"name":"Section of Surgical Pathology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Daw","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan"},{"name":"Genomics Research Center, Academia Sinica, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shie-Liang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan"},{"name":"Genomics Research Center, Academia Sinica, Taipei, Taiwan"},{"name":"Immunology Research Center, National Yang-Ming University and Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830171016"},{"key":"e_1_3_2_3_2","first-page":"1436","volume":"84","year":"2000","unstructured":"Cahill, M., B. 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