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Acellular pertussis vaccines (aPV) contain alum as the adjuvant and elicit Th2-biased immune responses that are less effective in protecting against infection than the reactogenic whole-cell pertussis vaccines (wPV), which elicit primarily a Th1\/Th17 response. An important goal for the field is to devise aPV that will induce immune responses similar to those of wPV. We show that Bordetella colonization factor A (BcfA), an outer membrane protein from<jats:named-content content-type=\"genus-species\">Bordetella bronchiseptica<\/jats:named-content>, has strong adjuvant function and elicits cellular and humoral immune responses to heterologous and<jats:named-content content-type=\"genus-species\">Bordetella pertussis<\/jats:named-content>antigens. Addition of BcfA to a commercial aPV resulted in greater reduction of<jats:named-content content-type=\"genus-species\">B. pertussis<\/jats:named-content>numbers from the lungs than that elicited by aPV alone. The more-efficient pathogen clearance was accompanied by increased interleukin-17 (IL-17) and reduced IL-5 and an increased ratio of IgG2\/IgG1 antibodies. Thus, our results suggest that BcfA improves aPV-induced responses by modifying the alum-induced Th2-biased aPV response toward Th1\/Th17. A redesigned aPV containing BcfA may allow better control of pertussis reemergence by reshaping immune responses to resemble those elicited by wPV immunization.<\/jats:p>","DOI":"10.1128\/iai.00935-17","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T12:36:24Z","timestamp":1520858184000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["The Adjuvant Bordetella Colonization Factor A Attenuates Alum-Induced Th2 Responses and Enhances Bordetella pertussis Clearance from Mouse Lungs"],"prefix":"10.1128","volume":"86","author":[{"given":"Jamie","family":"Jennings-Gee","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Quataert","sequence":"additional","affiliation":[{"name":"Human Immunology Center Laboratory, University of Rochester Medical Center, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tridib","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Ralph","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendar","family":"Deora","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"},{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"},{"name":"Department of Microbiology, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"},{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1","article-title":"Summary of notifiable diseases\u2014United States, 2005","volume":"54","author":"McNabb SJ","year":"2007","unstructured":"McNabb SJ, Jajosky RA, Hall-Baker PA, Adams DA, Sharp P, Anderson WJ, Javier AJ, Jones GJ, Nitschke DA, Worshams CA, Richard RA, Jr. 2007. 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