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Here, we found that in EHEC QseG interacts with the type III secretion system (T3SS) gate protein SepL and modulates the kinetics of attaching and effacing (AE) lesion formation on tissue-cultured cells. Moreover, an EHEC \u0394\n            <jats:italic>qseG<\/jats:italic>\n            mutant had reduced intestinal colonization in an infant rabbit model. Additionally, in\n            <jats:named-content content-type=\"genus-species\">Citrobacter rodentium<\/jats:named-content>\n            , an AE lesion-forming pathogen like EHEC, QseG is required for full virulence in a mouse model. In\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium, we found that QseG regulates the phase switch between the two flagellin types, FliC and FljB. In an\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium \u0394\n            <jats:italic>qseG<\/jats:italic>\n            mutant, the phase-variable promoter for\n            <jats:italic>fljB<\/jats:italic>\n            is preferentially switched into the \u201con\u201d position, leading to overproduction of this phase two flagellin. In infection of tissue-cultured cells, the\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium \u0394\n            <jats:italic>qseG<\/jats:italic>\n            mutant provokes increased inflammatory cytokine production versus the wild type;\n            <jats:italic>in vivo<\/jats:italic>\n            , in a murine infection model, the \u0394\n            <jats:italic>qseG<\/jats:italic>\n            strain caused a more severe inflammatory response and was attenuated versus the wild-type strain. Collectively, our findings demonstrate that QseG is important for full virulence in several enteric pathogens and controls flagellar phase variation in\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium, and they highlight both the complexity and conservation of the regulatory networks that control the virulence of enteric pathogens.\n          <\/jats:p>","DOI":"10.1128\/iai.00936-17","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T12:24:10Z","timestamp":1516364650000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["The QseG Lipoprotein Impacts the Virulence of Enterohemorrhagic Escherichia coli and Citrobacter rodentium and Regulates Flagellar Phase Variation in Salmonella enterica Serovar Typhimurium"],"prefix":"10.1128","volume":"86","author":[{"given":"Elizabeth A.","family":"Cameron","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA"},{"name":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, 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