{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:00:15Z","timestamp":1791597615357,"version":"4.3.4"},"reference-count":77,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5R01GMO62344-19"],"award-info":[{"award-number":["5R01GMO62344-19"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,8,19]]},"abstract":"<jats:p>A recent report by the National Institutes of Health on sepsis research has implied there is a trend to move away from mouse models of sepsis. The most commonly used animal model to study the pathogenesis of human sepsis is cecal ligation and puncture (CLP) in mice. The model has been the mainstay of sepsis research for decades and continues to be considered the gold standard to inform novel pathways of sepsis physiology and its therapeutic direction. As there have been many criticisms of the model, particularly regarding its relevance to human disease, how this model might be repurposed to be more reflective of the human condition begs discussion.<\/jats:p>","DOI":"10.1128\/iai.00942-19","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T08:56:08Z","timestamp":1592470568000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["Can the Cecal Ligation and Puncture Model Be Repurposed To Better Inform Therapy in Human Sepsis?"],"prefix":"10.1128","volume":"88","author":[{"given":"John C.","family":"Alverdy","sequence":"first","affiliation":[{"name":"University of Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Keskey","sequence":"additional","affiliation":[{"name":"University of Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Thewissen","sequence":"additional","affiliation":[{"name":"University of Chicago, Chicago, Illinois, USA"},{"name":"Radboud University Medical Center, Department of Surgery, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4MIR1118-425R"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1183-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30469-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.03.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7571"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0509-496"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(80)90037-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181922bd3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-016-0096-z"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03325-6"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148142"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.08.010"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403155"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00274.2014"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0266-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088501"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-587709"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00026"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2564"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep13721"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12254"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3180556d09"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318283cf9d"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130327"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00312.2005"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500896"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066618784861"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000330"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2014.166"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002173"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01220-05"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002172"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0806542"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32483-3"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-4804(66)80063-x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilx007"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7565"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2017.12.023"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01926"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20188707"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2194"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00664-17"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2016.021"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.9.6107"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2693-8"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00427-0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4A1215-581R"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.08.002"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.14.2.564-570.1976"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7124"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182360faf"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600940"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309728"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12726"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky471"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2543082"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-00987-2"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802188R"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-43492-5_5"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000731"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/10.supplement_2.s274"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro799"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1019"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30045-0"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16547"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006033"},{"key":"e_1_3_2_69_2","volume-title":"The grand design","author":"Hawking S","year":"2010","unstructured":"Hawking S, Mlodinow L. 2010. The grand design. Bantam Books, New York, NY."},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000153"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002291"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00903-19"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003004"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200304000-00003"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181c8fdb1"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001203"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01361-14"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318270e3ee"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00942-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00942-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T06:49:01Z","timestamp":1646462941000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00942-19"}},"subtitle":[],"editor":[{"given":"Karen M.","family":"Ottemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":77,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,8,19]]}},"alternative-id":["10.1128\/IAI.00942-19"],"URL":"https:\/\/doi.org\/10.1128\/iai.00942-19","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]},"assertion":[{"value":"2020-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00942-19"}}