{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:25:33Z","timestamp":1787667933193,"version":"build-2736575974"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI116119"],"award-info":[{"award-number":["1R01AI116119"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n                    elicits intestinal inflammation to gain access to nutrients. One of these nutrients is fructose-asparagine (F-Asn). The availability of F-Asn to\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    during infection is dependent upon\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    pathogenicity islands 1 and 2, which in turn are required to provoke inflammation. Here, we determined that F-Asn is present in mouse chow at approximately 400 pmol\/mg (dry weight). F-Asn is also present in the intestinal tract of germfree mice at 2,700 pmol\/mg (dry weight) and in the intestinal tract of conventional mice at 9 to 28 pmol\/mg. These findings suggest that the mouse intestinal microbiota consumes F-Asn. We utilized heavy-labeled precursors of F-Asn to monitor its formation in the intestine, in the presence or absence of inflammation, and none was observed. Finally, we determined that some members of the class\n                    <jats:named-content content-type=\"genus-species\">Clostridia<\/jats:named-content>\n                    encode F-Asn utilization pathways and that they are eliminated from highly inflamed\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    -infected mice. Collectively, our studies identify the source of F-Asn as the diet and that\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    -mediated inflammation is required to eliminate competitors and allow the pathogen nearly exclusive access to this nutrient.\n                  <\/jats:p>","DOI":"10.1128\/iai.00945-17","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T12:17:33Z","timestamp":1522239453000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Salmonella-Mediated Inflammation Eliminates Competitors for Fructose-Asparagine in the Gut"],"prefix":"10.1128","volume":"86","author":[{"given":"Jikang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anice","family":"Sabag-Daigle","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla A.","family":"Borton","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea F. M.","family":"Kop","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake E.","family":"Szkoda","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA"},{"name":"The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke L.","family":"Deatherage Kaiser","sequence":"additional","affiliation":[{"name":"Signature Sciences and Technology Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Renslow","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Wei","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie D.","family":"Nicora","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl K.","family":"Weitz","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua N.","family":"Adkins","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O.","family":"Metz","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper","family":"Boyaka","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkat","family":"Gopalan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly C.","family":"Wrighton","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki H.","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M. 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