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Four alleles (<jats:italic>Nramp1A<\/jats:italic>, -<jats:italic>B<\/jats:italic>, -<jats:italic>C<\/jats:italic>, and -<jats:italic>D<\/jats:italic>) were detected in the 3\u2032 untranslated region of the<jats:italic>Nramp1<\/jats:italic>gene. The<jats:italic>BB<\/jats:italic>genotype was represented among only controls, providing evidence that this genotype confers resistance to<jats:italic>Brucella abortus<\/jats:italic>. The monocytes from the BB (resistant) subjects displayed a higher basal level of<jats:italic>Nramp1<\/jats:italic>mRNA and a lower number of viable intracellular bacteria than did the monocytes from AA (susceptible) subjects. The higher basal level of the antibacterial protein Nramp1 most probably provides the BB animals with the possibility of controlling bacteria immediately after their entry inside the cell.<\/jats:p>","DOI":"10.1128\/iai.00948-06","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T01:33:53Z","timestamp":1165282433000},"page":"988-996","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Protective Effect of the Nramp1 BB Genotype against<i>Brucella abortus<\/i>in the Water Buffalo (<i>Bubalus bubalis<\/i>)"],"prefix":"10.1128","volume":"75","author":[{"given":"Rosanna","family":"Capparelli","sequence":"first","affiliation":[{"name":"Faculty of Biotechnological Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Alfano","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale per il Mezzogiorno, Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Amoroso","sequence":"additional","affiliation":[{"name":"Chair of Immunology, Faculty of Agriculture, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Borriello","sequence":"additional","affiliation":[{"name":"Chair of Immunology, Faculty of Agriculture, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Fenizia","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale per il Mezzogiorno, Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bianco","sequence":"additional","affiliation":[{"name":"Regione Campania, Assessorato all'Agricoltura, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sante","family":"Roperto","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Roperto","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Iannelli","sequence":"additional","affiliation":[{"name":"Chair of Immunology, Faculty of Agriculture, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.64.1081"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307954200"},{"key":"e_1_3_2_4_2","unstructured":"Alton G. 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