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Although the virulence genes of\n                    <jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>\n                    have been extensively studied, the mechanisms by which they damage the central immune organs have rarely been studied. In the current work, we wanted to uncover more details about the impact and mechanisms of\n                    <jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>\n                    on specific populations of thymic and immune cells in infected mice.\n                  <\/jats:p>","DOI":"10.1128\/iai.00950-19","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T09:01:21Z","timestamp":1578646881000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Streptococcus suis Serotype 2 Infection Causes Host Immunomodulation through Induction of Thymic Atrophy"],"prefix":"10.1128","volume":"88","author":[{"given":"Shujie","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Lyu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixin","family":"Duan","sequence":"additional","affiliation":[{"name":"Animal Science and Technology College, Heilongjiang Bayi Agriculture University, Daqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fandan","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijun","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics, College of Liberal Arts and Sciences, Iowa State University, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganwu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.4.1750-1756.1999"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030151"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12364"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200453"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03319"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.09.027"},{"key":"e_1_3_2_8_2","first-page":"480","article-title":"Relationship between DNA nuclease and the virulence of Streptococcus suis serotype 9","volume":"57","author":"Huanyu T","year":"2017","unstructured":"Huanyu T, Ren H, Wu Z, Lu C. 2017. 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