{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:35:35Z","timestamp":1790724935418,"version":"4.1.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI146909"],"award-info":[{"award-number":["AI146909"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI119437"],"award-info":[{"award-number":["AI119437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,5,20]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>\n            encodes a functional homolog of canonical Lon protease termed Lon-2. In addition,\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            encodes a second Lon homolog called Lon-1. Recent studies suggest that Lon-1 may function differently from the prototypical Lon protease. However, the function of Lon-1 in\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            biology remains virtually unknown. Particularly, the contribution of Lon-1 to\n            <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n            fitness and infection remains hitherto unexplored.\n          <\/jats:p>","DOI":"10.1128\/iai.00951-19","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T11:19:42Z","timestamp":1584616782000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["The Lon-1 Protease Is Required by Borrelia burgdorferi To Infect the Mammalian Host"],"prefix":"10.1128","volume":"88","author":[{"given":"Christina","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidoya","family":"Parrilla","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5940-4_2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2006.05.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2009.08.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04452.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2003.09.003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2016.03.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(97)00196-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000676"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5419-5432.2004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14460"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-44"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13206"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.11.6433-6445.2004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.182.10.2909-2918.2000"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2714"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134040"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.397"},{"key":"e_1_3_2_20_2","first-page":"167","article-title":"Ticks and Borrelia: model systems for investigating pathogen-arthropod interactions","volume":"5","author":"Schwan TG","year":"1996","unstructured":"Schwan TG. 1996. Ticks and Borrelia: model systems for investigating pathogen-arthropod interactions. Infect Agents Dis 5:167\u2013181.","journal-title":"Infect Agents Dis"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.1993.11442776"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12609"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12390"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(03)00097-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00186-17"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04353.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049123"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00076-16"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000435"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01726.x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.71.2.690-696.2003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12213"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13221"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01136-18"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/523764"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12377"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00360-16"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14243"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00404-16"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.31.5.1251-1255.1993"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812999106"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7383-5_15"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00131"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13545"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084625"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.1.133"},{"key":"e_1_3_2_47_2","first-page":"959","article-title":"Chronic Lyme borreliosis in the laboratory mouse","volume":"143","author":"Barthold SW","year":"1993","unstructured":"Barthold SW, de Souza MS, Janotka JL, Smith AL, Persing DH. 1993. Chronic Lyme borreliosis in the laboratory mouse. Am J Pathol 143:959\u2013971.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_48_2","first-page":"263","article-title":"Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice","volume":"139","author":"Barthold SW","year":"1991","unstructured":"Barthold SW, Persing DH, Armstrong AL, Peeples RA. 1991. Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice. Am J Pathol 139:263\u2013273.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.10.027"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/019992-0"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01555-13"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00297-16"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001272"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00951-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00951-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:45:03Z","timestamp":1646480703000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00951-19"}},"subtitle":[],"editor":[{"given":"Andreas J.","family":"B\u00e4umler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5,20]]}},"alternative-id":["10.1128\/IAI.00951-19"],"URL":"https:\/\/doi.org\/10.1128\/iai.00951-19","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,20]]},"assertion":[{"value":"2019-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00951-19"}}