{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:05:46Z","timestamp":1787789146160,"version":"build-2784847793"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of\n            <jats:italic>Ureaplasma parvum<\/jats:italic>\n            . Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO\/KC, interleukin-1\u03b1 (IL-1\u03b1), and IL-1\u03b2. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues.\n          <\/jats:p>","DOI":"10.1128\/iai.00984-06","type":"journal-article","created":{"date-parts":[[2006,11,21]],"date-time":"2006-11-21T01:05:37Z","timestamp":1164071137000},"page":"6656-6664","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Rat Strains Differ in Susceptibility to\n            <i>Ureaplasma parvum<\/i>\n            -Induced Urinary Tract Infection and Struvite Stone Formation"],"prefix":"10.1128","volume":"74","author":[{"given":"Leticia","family":"Reyes","sequence":"first","affiliation":[{"name":"University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Reinhard","sequence":"additional","affiliation":[{"name":"University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"O'Donell","sequence":"additional","affiliation":[{"name":"University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Stevens","sequence":"additional","affiliation":[{"name":"University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. 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