{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:44:54Z","timestamp":1785887094308,"version":"3.56.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NIH","award":["R01-AI\/DK49316"],"award-info":[{"award-number":["R01-AI\/DK49316"]}]},{"name":"NIH","award":["R01-DK083418"],"award-info":[{"award-number":["R01-DK083418"]}]},{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"crossref","award":["CRIS project #1235-51000-055"],"award-info":[{"award-number":["CRIS project #1235-51000-055"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Nematode infection upregulates interleukin-4 (IL-4) and IL-13 and induces STAT6-dependent changes in gut function that promote worm clearance. IL-4 and IL-13 activate the type 2 IL-4 receptor (IL-4R), which contains the IL-13R\u03b11 and IL-4R\u03b1 chains. We used mice deficient in IL-13R\u03b11 (IL-13R\u03b11<jats:sup>\u2212\/\u2212<\/jats:sup>) to examine the contribution of IL-13 acting at the type 2 IL-4R to immune and functional responses to primary (Hb1) and secondary (Hb2) infections with the gastrointestinal nematode parasite<jats:named-content content-type=\"genus-species\">Heligmosomoides bakeri<\/jats:named-content>. There were differences between strains in the IL-4 and IL-13 expression responses to Hb1 but not Hb2 infection. Following Hb2 infection, deficient mice had impaired worm expulsion and higher worm fecundity despite normal production of Th2-derived cytokines. The upregulation of IL-25 and IL-13R\u03b12 in Hb1- and Hb2-infected wild-type (WT) mice was absent in IL-13R\u03b11<jats:sup>\u2212\/\u2212<\/jats:sup>mice. Goblet cell numbers and resistin-like molecule beta (RELM-\u03b2) expression were attenuated significantly in IL-13R\u03b11<jats:sup>\u2212\/\u2212<\/jats:sup>mice following Hb2 infections. IL-13R\u03b11 contributes to the development of alternatively activated macrophages, but the type 1 IL-4R is also important. Hb1 infection had no effects on smooth muscle function or epithelial permeability in either strain, while the enhanced mucosal permeability and changes in smooth muscle function and morphology observed in response to Hb2 infection in WT mice were absent in IL-13R\u03b11<jats:sup>\u2212\/\u2212<\/jats:sup>mice. Notably, the contribution of claudin-2, which has been linked to IL-13, does not mediate the increased mucosal permeability following Hb2 infection. These results show that activation of IL-13R\u03b11 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion.<\/jats:p>","DOI":"10.1128\/iai.00990-15","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T03:48:57Z","timestamp":1453780137000},"page":"1032-1044","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Interleukin-13 Receptor \u03b11-Dependent Responses in the Intestine Are Critical to Parasite Clearance"],"prefix":"10.1128","volume":"84","author":[{"given":"Rex","family":"Sun","sequence":"first","affiliation":[{"name":"Departments of Radiation Oncology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joseph F.","family":"Urban","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, Beltsville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Notari","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B.","family":"Madden","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Bohl","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirumalai R.","family":"Ramalingam","sequence":"additional","affiliation":[{"name":"Division of Parasitology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wynn","sequence":"additional","affiliation":[{"name":"Division of Parasitology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terez","family":"Shea-Donohue","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"51","article-title":"Helminths and the modulation of mucosal inflammation","volume":"21","author":"Elliott DE","year":"2005","unstructured":"Elliott DE, Summers RW, Weinstock JV. 2005. Helminths and the modulation of mucosal inflammation. Curr Opin Gastroenterol 21:51\u201358.","journal-title":"Curr Opin Gastroenterol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80070-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00192.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.214965"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804299"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141142"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095906"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1544"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004159"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21628"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.491"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.9.5859"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1332"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1683"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0347-3"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.4049\/jimmunol.154.9.4675","article-title":"IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice","volume":"154","author":"Urban JF","year":"1995","unstructured":"Urban JF, Maliszewski CR, Madden KB, Katona IM, Finkelman FD. 1995. IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice. J Immunol 154:4675\u20134684.","journal-title":"J Immunol"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5616"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.2.948"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000450"},{"key":"e_1_3_3_22_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2011","unstructured":"National Research Council. 2011. Guide for the care and use of laboratory animals, 8th ed. National Academies Press, Washington, DC.","edition":"8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.077"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1451"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091268"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.013"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2563"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2234"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4417"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.4049\/jimmunol.147.4.1387","article-title":"Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis","volume":"147","author":"Madden KB","year":"1991","unstructured":"Madden KB, Urban JF, Jr, Ziltener HJ, Schrader JW, Finkelman FD, Katona IM. 1991. Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J Immunol 147:1387\u20131391.","journal-title":"J Immunol"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015593232347"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.505"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2424"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074026"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21299"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.045"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102057"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.064808"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700316"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02987.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00332-1"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01557.x"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00990-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00990-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T23:45:28Z","timestamp":1718322328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00990-15"}},"subtitle":[],"editor":[{"given":"J. A.","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1128\/IAI.00990-15"],"URL":"https:\/\/doi.org\/10.1128\/iai.00990-15","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"2015-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}