{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:25:54Z","timestamp":1791275154758,"version":"4.1.0"},"reference-count":59,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The association between extreme-prematurity births and intrauterine infection emphasizes the importance of understanding the host immune responses against uterine-invading microbes during early pregnancy to the prevention of preterm births.<jats:italic>Listeria monocytogenes<\/jats:italic>, a clinically relevant intracellular bacterium, has a predilection for replication at the maternofetal interface during pregnancy. Here, using mice carrying the recessive null osteopetrotic mutation in the colony-stimulating factor-1 (CSF-1) gene, we show that CSF-1-dependent macrophage functions are required for the maternal decidua immune responses against<jats:italic>L. monocytogenes<\/jats:italic>infections during early gestation in mice. In the absence of CSF-1, pregnant mice were more susceptible to uterine infection by<jats:italic>L. monocytogenes<\/jats:italic>; their inability to control the expansion of colonized bacteria in the pregnant uterus led to decidual cell death, tissue disintegration, and resorption of the developing embryo. However, CSF-1-deficient mice were able to produce significant levels of both Th1 cytokines and neutrophil chemoattractants and to recruit neutrophils to the decidual tissue in response to<jats:italic>Listeria<\/jats:italic>infection. Depletion of macrophages in hormonally induced pseudopregnant mice resulted in higher uterine bacterial levels after<jats:italic>L. monocytogenes<\/jats:italic>infection. These data suggest that the anti-<jats:italic>Listeria<\/jats:italic>responses in the maternal decidual tissue are dependent on CSF-1-regulated macrophages.<\/jats:p>","DOI":"10.1128\/iai.01022-08","type":"journal-article","created":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T00:26:24Z","timestamp":1223943984000},"page":"85-97","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Colony-Stimulating Factor-1-Dependent Macrophage Functions Regulate the Maternal Decidua Immune Responses against<i>Listeria monocytogenes<\/i>Infections during Early Gestation in Mice"],"prefix":"10.1128","volume":"77","author":[{"given":"Xuan","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Developmental and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Developmental and Molecular Biology"},{"name":"Department of Obstetrics and Gynecology and Women's Health"},{"name":"Center for the Study of Reproductive Biology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Pollard","sequence":"additional","affiliation":[{"name":"Department of Developmental and Molecular Biology"},{"name":"Department of Obstetrics and Gynecology and Women's Health"},{"name":"Center for the Study of Reproductive Biology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.162.3.1685","volume":"162","year":"1999","unstructured":"Ajuebor, M. 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