{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:33:34Z","timestamp":1787016814786,"version":"build-2736575974"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The Mongolian gerbil model of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection resembles human gastritis. In this study, we investigated the role of NF-\u03baB activation in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected gerbils. Activated macrophages were significantly increased in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected gastric mucosa and were identified as being important cells with potent activation of NF-\u03baB, which plays an important part in producing proinflammatory cytokines. Macrophage depletion by the administration of clodronate resulted in milder inflammation in gerbils infected with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . In macrophages, the inhibition of I\u03baB kinase \u03b2 (IKK\u03b2), which is a critical kinase for NF-\u03baB activation, resulted in lower proinflammatory cytokine expression caused by heat-killed\n                    <jats:italic>H. pylori<\/jats:italic>\n                    cells. Furthermore, treatment with IKK\u03b2 inhibitor resulted in milder inflammation in gerbils with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    gastritis. Collectively, our data suggest that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -mediated gastric inflammation critically depends on the efficient recruitment and activation of macrophages, with sufficient NF-\u03baB activation.\n                  <\/jats:p>","DOI":"10.1128\/iai.01046-07","type":"journal-article","created":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T20:34:33Z","timestamp":1197318873000},"page":"781-787","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Activation of I\u03baB Kinase \u03b2 and NF-\u03baB Is Essential for\n                    <i>Helicobacter pylori<\/i>\n                    -Induced Chronic Gastritis in Mongolian Gerbils"],"prefix":"10.1128","volume":"76","author":[{"given":"Ayako","family":"Yanai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005"},{"name":"Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Maeda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005"},{"name":"Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shibata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005"},{"name":"Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohko","family":"Hikiba","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Ohmae","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 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