{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:36:34Z","timestamp":1790890594421,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interleukin-10 (IL-10)-deficient mice are resistant to several pathogens, including\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    . Surprisingly, we observed that heterozygous IL-10\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice also survive high-dose intravenous infection with\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    KIM5 (Pgm\n                    <jats:sup>\u2212<\/jats:sup>\n                    ). Analysis of commercial IL-10\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice revealed that at least 30 cM of genomic DNA from the original 129 strain remains, including a functional Slc11a1 (Nramp1) gene. Interestingly, two substrains of 129 mice were resistant to high-dose\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    KIM5. Resistance does not appear to be recessive, as F\n                    <jats:sub>1<\/jats:sub>\n                    mice (C57BL\/6J \u00d7 129) also survived a high-dose challenge. A QTL-based genetic scan of chromosome 1 with 35 infected F\n                    <jats:sub>1<\/jats:sub>\n                    backcrossed mice revealed that resistance to KIM5 maps to a region near IL-10. Two novel IL-10\n                    <jats:sup>+\/+<\/jats:sup>\n                    mouse strains which each possess most of the original 30-cM stretch of 129 DNA maintained resistance to high-dose infection with\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    KIM5 even in a heterozygous state. Conversely, a novel IL-10\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mouse strain in which most of the 129 DNA has been crossed out exhibited intermediate resistance to KIM5, while the corresponding IL-10\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    strain was completely susceptible. Taken together, these results demonstrate that 129-derived genomic DNA near IL-10 confers resistance to\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    KIM5 and contributes to the observed resistance of IL-10\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice.\n                  <\/jats:p>","DOI":"10.1128\/iai.01057-08","type":"journal-article","created":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T20:15:07Z","timestamp":1225138507000},"page":"367-373","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Substrains of 129 Mice Are Resistant to\n                    <i>Yersinia pestis<\/i>\n                    KIM5: Implications for Interleukin-10-Deficient Mice"],"prefix":"10.1128","volume":"77","author":[{"given":"Joshua K.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Tapping","sequence":"additional","affiliation":[{"name":"Department of Microbiology"},{"name":"College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01497-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3673-3681.2003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.09.006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00597-06"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm932"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-72124-8_38"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.7.3919"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1458"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2005.00349.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70577-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.8.3021-3029.1995"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.4.1196-1203.1997"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.5152-5159.2005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.35"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1532-1542.2005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01644-06"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.04.003"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0707-669"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80958-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504728102"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1315"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020908"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00277"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00990.x"},{"key":"e_1_3_2_26_2","unstructured":"Infect. 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