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In this study, we extend these findings to include a large panel of fibrosis-associated markers. We developed a multiplex bead-based assay to measure the levels of 35 proteins associated with fibrosis. Cord blood from 109 neonates born to mothers residing in an area of<jats:named-content content-type=\"genus-species\">Schistosoma japonicum<\/jats:named-content>endemicity was assessed for these molecules. Ten mediators were elevated in the cord blood from schistosome-infected pregnancies, including insulin-like growth factor 1 (IGF-1), tumor growth factor \u03b21 (TGF-\u03b21), connective tissue growth factor (CTGF), procollagen I carboxy-terminal propeptide (PICP), amino-telopeptide of type 1 collagen (ICTP), collagen VI, desmosine, matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 1 (TIMP-1), and TIMP-4. Many of these were also positively correlated with preterm birth (PICP, ICTP, MMP-2, TGF-\u03b21, desmosine, CTGF, TIMP-1). In addition, birth weight was 168 g lower for infants with detectable levels of CTGF than for those with CTGF levels below the level of detection. Maternal schistosomiasis results in upregulation of fibrosis-associated proteins in the cord blood of the neonate, a subset of which are also associated with adverse birth outcomes. As the first report of fibrosis-associated molecules altered in the newborn of infected mothers, this study has broad implications for the health of the fetus, stretching from gestation to adulthood.<\/jats:p>","DOI":"10.1128\/iai.01060-13","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T03:20:30Z","timestamp":1383016830000},"page":"350-355","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Maternal Infection with Schistosoma japonicum Induces a Profibrotic Response in Neonates"],"prefix":"10.1128","volume":"82","author":[{"given":"Emily A.","family":"McDonald","sequence":"first","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA"},{"name":"Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Cheng","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA"},{"name":"Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Jarilla","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne J.","family":"Sagliba","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annaliza","family":"Gonzal","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amabelle J.","family":"Amoylen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remigio","family":"Olveda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Acosta","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA"},{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baylink","sequence":"additional","affiliation":[{"name":"Department of Medicine, Loma Linda University, Loma Linda, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer F.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA"},{"name":"Department of Pediatrics, Rhode Island Hospital, Brown University Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Kurtis","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA"},{"name":"Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.02.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/588826"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/430929"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/510313"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4049\/jimmunol.153.2.753","article-title":"Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis","volume":"153","author":"Cheever A","year":"1994","unstructured":"CheeverAWilliamsMWynnTAFinkelmanFSederRCoxTHienySCasparPSherA. 1994. 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