{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:56Z","timestamp":1787016776098,"version":"build-2736575974"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Natural immunity against\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    is thought to develop following nasopharyngeal colonization with this bacterium or other microbes expressing cross-reactive antigens.\n                    <jats:italic>Neisseria lactamica<\/jats:italic>\n                    is a commensal of the upper respiratory tract which is often carried by infants and young children; epidemiological evidence indicates that colonization with this bacterium can elicit serum bactericidal activity (SBA) against\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    , the most validated correlate of protective immunity. Here we demonstrate experimentally that immunization of mice with live\n                    <jats:italic>N. lactamica<\/jats:italic>\n                    protects animals against lethal meningococcal challenge and that some, but not all, strains of\n                    <jats:italic>N. lactamica<\/jats:italic>\n                    elicit detectable SBA in immunized animals regardless of the serogroup of\n                    <jats:italic>N. meningitidis<\/jats:italic>\n                    . While it is unlikely that immunization with live\n                    <jats:italic>N. lactamica<\/jats:italic>\n                    will be implemented as a vaccine against meningococcal disease, understanding the basis for the induction of cross-protective immunity and SBA should be valuable in the design of subunit vaccines for the prevention of this important human infection.\n                  <\/jats:p>","DOI":"10.1128\/iai.01062-06","type":"journal-article","created":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T18:57:47Z","timestamp":1161370667000},"page":"6348-6355","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Immunization with Live\n                    <i>Neisseria lactamica<\/i>\n                    Protects Mice against Meningococcal Challenge and Can Elicit Serum Bactericidal Antibodies"],"prefix":"10.1128","volume":"74","author":[{"given":"Yanwen","family":"Li","sequence":"first","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Winterbotham","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mowe","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gorringe","sequence":"additional","affiliation":[{"name":"Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury SP4 0JG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Tang","sequence":"additional","affiliation":[{"name":"Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1999.0325"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.5.1710-1715.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.10.5.780-786.2003"},{"key":"e_1_3_2_5_2","first-page":"119","volume":"81","year":"2006","unstructured":"Anonymous. 2006. 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