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In murine models and two observational studies in humans, schistosome infection during pregnancy was associated with reduced birth weight, although a recent treatment trial in<jats:italic>Schistosoma mansoni<\/jats:italic>did not detect this association. We conducted an observational study among 99 pregnant women living in an area of<jats:italic>Schistosoma japonicum<\/jats:italic>endemicity in the Philippines. We enrolled women at 32 weeks gestation and measured<jats:italic>S. japonicum<\/jats:italic>and geohelminth infection intensity. We collected maternal peripheral blood at 32 weeks gestation and placental and cord blood at delivery to assess inflammatory status. At delivery, we collected a placental-tissue sample and measured birth weight. In multivariate models adjusted for geohelminths, maternal schistosomiasis was associated with increased levels of inflammatory cytokines in maternal peripheral (tumor necrosis factor alpha [TNF-\u03b1] and interleukin 10 [IL-10]), placental (TNF-\u03b1, IL-6, TNF-\u03b1 receptor II [RII], and IL-1\u03b2), and cord (IL-1\u03b2 and TNF-\u03b1 RII) blood, as well as acute subchorionitis and increased TNF-\u03b1 production by syncytiotrophoblasts assessed by immunohistochemistry (all<jats:italic>P<\/jats:italic>&lt; 0.05). After adjusting for confounders, placental IL-1\u03b2, and TNF-\u03b1 production by syncytiotrophoblasts was independently associated with decreased birth weight (both<jats:italic>P<\/jats:italic>&lt; 0.05). Our data indicate that maternal schistosomiasis results in a proinflammatory signature that is detectable in maternal, placental, and fetal compartments, and a subset of these responses are associated with decreased birth weight. This potential mechanistic link between maternal schistosomiasis and poor birth outcomes will contribute to the debate regarding treatment of maternal schistosome infections.<\/jats:p>","DOI":"10.1128\/iai.01072-10","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T04:43:35Z","timestamp":1292301815000},"page":"1254-1261","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":56,"title":["Maternal Schistosomiasis Japonica Is Associated with Maternal, Placental, and Fetal Inflammation"],"prefix":"10.1128","volume":"79","author":[{"given":"Jonathan D.","family":"Kurtis","sequence":"first","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"},{"name":"Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Higashi","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"},{"name":"Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusun","family":"Gundogan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Women and Infants Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surrendra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Women and Infants Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunthorn","family":"PondTor","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Jarilla","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marriane Joy","family":"Sagliba","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analisa","family":"Gonzal","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remigio","family":"Olveda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz","family":"Acosta","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"},{"name":"Department of Immunology, Research Institute of Tropical Medicine, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer F.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"},{"name":"Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"721","volume":"29","year":"1999","unstructured":"Abdel-Aaty, H. 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