{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:59:31Z","timestamp":1778921971370,"version":"3.51.4"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Infection with\n            <jats:italic>Helicobacter trogontum<\/jats:italic>\n            , a urease-positive helicobacter isolated from subclinically infected rats, was evaluated in B6.129P2-IL10\n            <jats:sup>\n              <jats:italic>tm1Cgn<\/jats:italic>\n            <\/jats:sup>\n            (interleukin-10\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            [IL-10\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            ]) and C57BL\/6 (B6) mice. In a first experiment, IL-10\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice naturally infected with\n            <jats:italic>Helicobacter rodentium<\/jats:italic>\n            had subclinical typhlocolitis but developed severe diarrhea and loss of body condition with erosive to ulcerative typhlocolitis within 1 to 3 weeks of experimental infection with\n            <jats:italic>H. trogontum<\/jats:italic>\n            . A second experiment demonstrated that helicobacter-free IL-10\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice dosed with\n            <jats:italic>H. trogontum<\/jats:italic>\n            also developed severe clinical signs and typhlocolitis within 2 to 4 weeks, whereas B6 mice colonized with\n            <jats:italic>H. trogontum<\/jats:italic>\n            were resistant to disease. In a third experiment, using helicobacter-free IL-10\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice, dosing with\n            <jats:italic>H. trogontum<\/jats:italic>\n            resulted in acute morbidity and typhlocolitis within 8 days. Acute typhlocolitis was accompanied by signs of sepsis supported by degenerative hemograms and recovery of\n            <jats:italic>Escherichia coli<\/jats:italic>\n            and\n            <jats:italic>Proteus<\/jats:italic>\n            spp. from the livers of infected mice. Quantitative PCR data revealed that\n            <jats:italic>H. rodentium<\/jats:italic>\n            and\n            <jats:italic>H. trogontum<\/jats:italic>\n            may compete for colonization of the lower bowel, as\n            <jats:italic>H. trogontum<\/jats:italic>\n            established higher colonization levels in the absence of\n            <jats:italic>H. rodentium<\/jats:italic>\n            (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.003).\n            <jats:italic>H. trogontum<\/jats:italic>\n            -induced typhlocolitis was also associated with a significant decrease in the levels of colonization by five of eight anaerobes that comprise altered Schaedler's flora (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.002). These results demonstrate for the first time that\n            <jats:italic>H. rodentium<\/jats:italic>\n            infection in IL-10\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice causes subclinical typhlocolitis and that infection with\n            <jats:italic>H. trogontum<\/jats:italic>\n            (with or without\n            <jats:italic>H. rodentium<\/jats:italic>\n            ) induces a rapid-onset, erosive to ulcerative typhlocolitis which impacts the normal anaerobic flora of the colon and increases the risk of sepsis.\n          <\/jats:p>","DOI":"10.1128\/iai.01091-06","type":"journal-article","created":{"date-parts":[[2006,11,21]],"date-time":"2006-11-21T01:05:37Z","timestamp":1164071137000},"page":"6615-6623","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Rapid Onset of Ulcerative Typhlocolitis in B6.129P2-IL10\n            <sup>\n              <i>tm1Cgn<\/i>\n            <\/sup>\n            (IL-10\n            <sup>\u2212\/\u2212<\/sup>\n            ) Mice Infected with\n            <i>Helicobacter trogontum<\/i>\n            Is Associated with Decreased Colonization by Altered Schaedler's Flora"],"prefix":"10.1128","volume":"74","author":[{"given":"M. T.","family":"Whary","sequence":"first","affiliation":[{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Danon","sequence":"additional","affiliation":[{"name":"CSIRO Molecular &amp; Health Technologies, North Ryde, New South Wales, Australia 1670"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Ge","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sundina","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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