{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:19:10Z","timestamp":1791098350673,"version":"4.1.0"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            , the causative agent of plague, must survive in blood in order to cause disease and to be transmitted from host to host by fleas. Members of the Ail\/Lom family of outer membrane proteins provide protection from complement-dependent killing for a number of pathogenic bacteria. The\n            <jats:italic>Y. pestis<\/jats:italic>\n            KIM genome is predicted to encode four Ail\/Lom family proteins.\n            <jats:italic>Y. pestis<\/jats:italic>\n            mutants specifically deficient in expression of each of these proteins were constructed using lambda Red-mediated recombination. The Ail outer membrane protein was essential for\n            <jats:italic>Y. pestis<\/jats:italic>\n            to resist complement-mediated killing at 26 and 37\u00b0C. Ail was expressed at high levels at both 26 and 37\u00b0C, but not at 6\u00b0C. Expression of Ail in\n            <jats:italic>Escherichia coli<\/jats:italic>\n            provided protection from the bactericidal activity of complement. High-level expression of the three other\n            <jats:italic>Y. pestis<\/jats:italic>\n            Ail\/Lom family proteins (the y1682, y2034, and y2446 proteins) provided no protection against complement-mediated bacterial killing. A\n            <jats:italic>Y. pestis ail<\/jats:italic>\n            deletion mutant was rapidly killed by sera obtained from all mammals tested except mouse serum. The role of Ail in infection of mice,\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            , and fleas was investigated.\n          <\/jats:p>","DOI":"10.1128\/iai.01125-07","type":"journal-article","created":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T02:08:18Z","timestamp":1195524498000},"page":"612-622","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":136,"title":["Resistance of\n            <i>Yersinia pestis<\/i>\n            to Complement-Dependent Killing Is Mediated by the Ail Outer Membrane Protein"],"prefix":"10.1128","volume":"76","author":[{"given":"Sara Schesser","family":"Bartra","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida 33101"},{"name":"Department of Molecular Biology, Umea\u030a University, 901 87 Umea\u030a, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"Styer","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna M.","family":"O'Bryant","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Nilles","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Joseph","family":"Hinnebusch","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIH, NIAID, Hamilton, Montana 59840"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Aballay","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory V.","family":"Plano","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida 33101"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.11.7324-7331.2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.1381-1386.2006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.03987.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.4.2232-2244.2005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.8.3561"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.6.1247"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.8778"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.11.7236-7242.2005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/417243a"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.16.4601-4611.2002"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.62.552"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.3.1106-1111.1991"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115972"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.11.5183-5186.1994"},{"key":"e_1_3_2_17_2","first-page":"197","volume":"7","year":"2005","unstructured":"Hinnebusch, B. 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