{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:35:28Z","timestamp":1787063728086,"version":"build-2736575974"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Previous studies have shown that cells and cytokines associated with interleukin-17 (IL-17)-driven inflammation are involved in the arthritic response to<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Borrelia burgdorferi<\/jats:named-content>infection. Here, we report that IL-17 is a contributing factor in the development of Lyme arthritis and show that its production and histopathological effects are regulated by interleukin-10 (IL-10). Spleen cells obtained from<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. burgdorferi<\/jats:named-content>-infected, \u201carthritis-resistant\u201d wild-type C57BL\/6 mice produced low levels of IL-17 following stimulation with the spirochete. In contrast, spleen cells obtained from infected, IL-10-deficient C57BL\/6 mice produced a significant amount of IL-17 following stimulation with<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. burgdorferi<\/jats:named-content>. These mice developed significant arthritis, including erosion of the bones in the ankle joints. We further show that treatment with antibody to IL-17 partially inhibited the significant hind paw swelling and histopathological changes observed in<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. burgdorferi<\/jats:named-content>-infected, IL-10-deficient mice. Taken together, these findings provide additional evidence of a role for IL-17 in Lyme arthritis and reveal an additional regulatory target of IL-10 following borrelial infection.<\/jats:p>","DOI":"10.1128\/iai.01129-13","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T03:04:40Z","timestamp":1379387080000},"page":"4421-4430","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Interleukin-10 (IL-10) Inhibits Borrelia burgdorferi-Induced IL-17 Production and Attenuates IL-17-Mediated Lyme Arthritis"],"prefix":"10.1128","volume":"81","author":[{"given":"Emily S.","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Wisconsin\u2014Milwaukee, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velinka","family":"Medi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Wisconsin\u2014Milwaukee, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kuo","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Departments of Pathobiological Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Warner","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"Schell","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Departments of Pathobiological Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Bacteriology, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Medical Microbiology and Immunology, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean T.","family":"Nardelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Wisconsin\u2014Milwaukee, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21681"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.6.2691-2697.1998"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.10.5142-5150.1999"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323655"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.3.593"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.160.2.1022","article-title":"T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis","volume":"160","author":"Gross DM","year":"1998","unstructured":"GrossDMSteereACHuberBT. 1998. T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis. J. Immunol. 160:1022\u20131028.","journal-title":"J. Immunol."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34383"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/art.27468","article-title":"Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis","volume":"62","author":"Shen S","year":"2010","unstructured":"ShenSShinJJStrleKMcHughGLiXGlicksteinLJDrouinEESteereAC. 2010. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis Rheum. 62:2127\u20132137.","journal-title":"Arthritis Rheum."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.7.3329-3333.1999"},{"key":"e_1_3_2_11_2","first-page":"44","article-title":"Destructive arthritis in vaccinated interferon gamma-deficient mice challenged with Borrelia burgdorferi: modulation by tumor necrosis factor alpha","volume":"10","author":"Christopherson JA","year":"2003","unstructured":"ChristophersonJAMunsonELEnglandDMCrokeCLRemingtonMCMolitorMLDeCosterDJCallisterSMSchellRF. 2003. Destructive arthritis in vaccinated interferon gamma-deficient mice challenged with Borrelia burgdorferi: modulation by tumor necrosis factor alpha. Clin. Diagn. Lab. Immunol. 10:44\u201352.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_12_2","first-page":"35","article-title":"Neutralization of gamma interferon augments borreliacidal antibody production and severe destructive Lyme arthritis in C3H\/HeJ mice","volume":"11","author":"Munson EL","year":"2004","unstructured":"MunsonELDeCosterDJNardelliDTEnglandDMCallisterSMSchellRF. 2004. Neutralization of gamma interferon augments borreliacidal antibody production and severe destructive Lyme arthritis in C3H\/HeJ mice. Clin. Diagn. Lab. Immunol. 11:35\u201341.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3437-3442.2003"},{"key":"e_1_3_2_14_2","first-page":"1075","article-title":"Association of CD4+CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody","volume":"11","author":"Nardelli DT","year":"2004","unstructured":"NardelliDTBurchillMAEnglandDMTorrealbaJCallisterSMSchellRF. 2004. Association of CD4+CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody. Clin. Diagn. Lab. Immunol. 11:1075\u20131084.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.2.289-296.2006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2008.00431.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2010.00721.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00129-08"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6107"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23972"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37875"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.020"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.1.133"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00330-07"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0681"},{"key":"e_1_3_2_26_2","first-page":"515","article-title":"Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases","volume":"35","author":"Agarwal S","year":"2008","unstructured":"AgarwalSMisraRAggarwalA. 2008. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J. Rheumatol. 35:515\u2013519.","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.11.006"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20001"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.7162-7165.2000"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400111"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102359"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5377"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10957"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03465.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir276"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003243"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.03.010"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.10.006"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1539"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.011"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05242-11"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00052-11"},{"key":"e_1_3_2_43_2","first-page":"786","article-title":"CD4+CD25+ T cells prevent arthritis associated with Borrelia vaccination and infection","volume":"12","author":"Nardelli DT","year":"2005","unstructured":"NardelliDTClouteJPLukKHKTorrealbaJWarnerTFCallisterSMSchellRF. 2005. CD4+CD25+ T cells prevent arthritis associated with Borrelia vaccination and infection. Clin. Diagn. Lab. Immunol. 12:786\u2013792.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00137-06"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37910"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01404-07"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6663-6669.2000"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.687-694.2001"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7930"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7076"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05451-11"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.03.018"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01129-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01129-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:31:23Z","timestamp":1715985083000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01129-13"}},"subtitle":[],"editor":[{"given":"A. J.","family":"B\u00e4umler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1128\/IAI.01129-13"],"URL":"https:\/\/doi.org\/10.1128\/iai.01129-13","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"2013-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}