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We have used this assay to characterize the interactions of\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    promastigotes with \u223c70 mammalian host biomolecules (extracellular proteins, glycosaminoglycans, growth factors, cell surface receptors). We have identified, in total, 27 new partners (23 proteins, 4 glycosaminoglycans) of procyclic promastigotes of six\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    species and 18 partners (15 proteins, 3 glycosaminoglycans) of three species of stationary-phase promastigotes for all the strains tested. The diversity of the interaction repertoires of\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    parasites reflects their dynamic and complex interplay with their mammalian hosts, which depends mostly on the species and strains of\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    . Stationary-phase\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    parasites target extracellular matrix proteins and glycosaminoglycans, which are highly connected in the extracellular interaction network. Heparin and heparan sulfate bind to most\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    strains tested, and 6-\n                    <jats:italic>O<\/jats:italic>\n                    -sulfate groups play a crucial role in these interactions. Numerous\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    strains bind to tropoelastin, and some strains are even able to degrade it. Several strains interact with collagen VI, which is expressed by macrophages. Most\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    promastigotes interact with several regulators of angiogenesis, including antiangiogenic factors (endostatin, anastellin) and proangiogenic factors (ECM-1, VEGF, and TEM8 [also known as anthrax toxin receptor 1]), which are regulated by hypoxia. Since hypoxia modulates the infection of macrophages by the parasites, these interactions might influence the infection of host cells by\n                    <jats:named-content content-type=\"genus-species\">Leishmania<\/jats:named-content>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/iai.01146-13","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T23:25:37Z","timestamp":1385421937000},"page":"594-606","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Large-Scale Investigation of Leishmania Interaction Networks with Host Extracellular Matrix by Surface Plasmon Resonance Imaging"],"prefix":"10.1128","volume":"82","author":[{"given":"Marie","family":"Fatoux-Ardore","sequence":"first","affiliation":[{"name":"UMR 5086 CNRS\u2014Universit\u00e9 Lyon 1, Institut de Biologie et Chimie des Prot\u00e9ines, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Peysselon","sequence":"additional","affiliation":[{"name":"UMR 5086 CNRS\u2014Universit\u00e9 Lyon 1, Institut de Biologie et Chimie des Prot\u00e9ines, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Weiss","sequence":"additional","affiliation":[{"name":"School of Molecular Bioscience, University of Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bastien","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Montpellier 1, Centre National de R\u00e9f\u00e9rence des Leishmanioses, UMR MIVEGEC (CNRS 5290, IRD 224, UM1, UM2), D\u00e9partement de Parasitologie-Mycologie, CHRU de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Pratlong","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Montpellier 1, Centre National de R\u00e9f\u00e9rence des Leishmanioses, UMR MIVEGEC (CNRS 5290, IRD 224, UM1, UM2), D\u00e9partement de Parasitologie-Mycologie, CHRU de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Ricard-Blum","sequence":"additional","affiliation":[{"name":"UMR 5086 CNRS\u2014Universit\u00e9 Lyon 1, Institut de Biologie et Chimie des Prot\u00e9ines, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Control of the leishmaniases. 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