{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:56:25Z","timestamp":1761058585984},"reference-count":21,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Immunization with a cell wall\/membrane (CW\/M) and yeast cytosol extract (YCE) crude antigen from\n            <jats:italic>Blastomyces dermatitidis<\/jats:italic>\n            confers T-cell-mediated resistance against lethal experimental infection in mice. We isolated and characterized T cells that recognize components of these protective antigens and mediate protection. CD4\n            <jats:sup>+<\/jats:sup>\n            T-cell clones elicited with CW\/M antigen adoptively transferred protective immunity when they expressed a V\u03b12\n            <jats:sup>+<\/jats:sup>\n            J\u03b149\n            <jats:sup>+<\/jats:sup>\n            \/V\u03b21\n            <jats:sup>+<\/jats:sup>\n            J\u03b21.1\n            <jats:sup>+<\/jats:sup>\n            heterodimeric T-cell receptor (TCR) and produced high levels of gamma interferon (IFN-\u03b3). In contrast, V\u03b28.1\/8.2\n            <jats:sup>+<\/jats:sup>\n            CD4\n            <jats:sup>+<\/jats:sup>\n            T-cell clones that were reactive against CW\/M and YCE antigens and produced little or no IFN-\u03b3 either failed to mediate protection or exacerbated the infection depending on the level of interleukin-5 expression. Thus, the outgrowth of protective T-cell clones against immunodominant antigens of\n            <jats:italic>B. dermatitidis<\/jats:italic>\n            is biased by a combination of the TCR repertoire and Th1 cytokine production.\n          <\/jats:p>","DOI":"10.1128\/iai.01148-06","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T23:51:25Z","timestamp":1166658685000},"page":"193-200","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["V\u03b21\n            <sup>+<\/sup>\n            J\u03b21.1\n            <sup>+<\/sup>\n            \/V\u03b12\n            <sup>+<\/sup>\n            J\u03b149\n            <sup>+<\/sup>\n            CD4\n            <sup>+<\/sup>\n            T Cells Mediate Resistance against Infection with\n            <i>Blastomyces dermatitidis<\/i>"],"prefix":"10.1128","volume":"75","author":[{"given":"Marcel","family":"Wu\u0308thrich","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna I.","family":"Filutowicz","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly L.","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Cincinnati College of Medicine and Veterans Affairs Hospital, Cincinnati, Ohio 45267"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S.","family":"Deepe","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Cincinnati College of Medicine and Veterans Affairs Hospital, Cincinnati, Ohio 45267"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce S.","family":"Klein","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Internal Medicine"},{"name":"Medical Microbiology and Immunology"},{"name":"Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-305X(03)00027-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.8.1207"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.6.1371"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/342602"},{"key":"e_1_3_2_6_2","first-page":"611","year":"1993","unstructured":"Fisher, L. D., and G. van Belle. 1993. Biostatistics: a methodology for the health sciences, p. 611-613. John Wiley & Sons, Inc., New York, NY.","journal-title":"Biostatistics: a methodology for the health sciences"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.1.330-336.1991"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2963"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2855"},{"key":"e_1_3_2_10_2","first-page":"695","volume":"117","year":"1978","unstructured":"Harvey, R. P., E. S. Schmid, C. C. Carrington, and D. A. Stevens. 1978. Mouse model of pulmonary blastomycosis: utility, simplicity, and quantitative parameters. Am. Rev. Respir. Dis.117:695-703.","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948049"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199309000-00003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8451641"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1255"},{"key":"e_1_3_2_15_2","first-page":"911","volume":"120","year":"1979","unstructured":"Sarosi, G. A., and S. F. Davies. 1979. Blastomycosis. Am. Rev. Respir. Dis.120:911-938.","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.10.5818"},{"key":"e_1_3_2_17_2","first-page":"337","year":"2001","unstructured":"W\u00fcthrich, M., H. I. Filutowicz, and B. S. Klein. 2001. Molecular and cellular determinants of vaccine immunity to Blastomyces dermatitidis, abstr. E-41, p. 337. 101st Gen. Meet. Am. Soc. Microbiol. American Society for Microbiology, Washington, DC.","journal-title":"Molecular and cellular determinants of vaccine immunity to Blastomyces dermatitidis"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11037"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030109"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6969"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5538"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5288"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01148-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01148-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T06:54:52Z","timestamp":1646463292000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01148-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1128\/IAI.01148-06"],"URL":"https:\/\/doi.org\/10.1128\/iai.01148-06","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2006-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}