{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:45:18Z","timestamp":1757702718091},"reference-count":73,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Neurocysticercosis (NCC) is a central nervous system (CNS) infection caused by the metacestode stage of the parasite<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Taenia solium<\/jats:named-content>. During NCC, the parasites release immunodominant glycan antigens in the CNS environment, invoking immune responses. The majority of the associated pathogenesis is attributed to the immune response against the parasites. Glycans from a number of pathogens, including helminths, act as pathogen-associated molecular pattern molecules (PAMPs), which are recognized by pattern recognition receptors (PRRs) known as C-type lectin receptors (CLRs). Using a mouse model of NCC by infection with the related parasite<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mesocestoides corti<\/jats:named-content>, we have investigated the role of mannose receptor C type 1 (MRC1), a CLR which recognizes high-mannose-containing glycan antigens. Here we show that MRC1<jats:sup>\u2212\/\u2212<\/jats:sup>mice exhibit increased survival times after infection compared with their wild-type (WT) counterparts. The decreased disease severity correlates with reduced levels of expression of markers implicated in NCC pathology, such as interleukin-1\u03b2 (IL-1\u03b2), IL-6, CCL5, and matrix metalloproteinase 9 (MMP9), in addition to induction of an important repair marker, fibroblast growth factor 2 (FGF2). Furthermore, the immune cell subsets that infiltrate the brain of MRC1<jats:sup>\u2212\/\u2212<\/jats:sup>mice are dramatically altered and characterized by reduced numbers of T cells and the accumulation of granulocytic cells with an immune phenotype resembling granulocytic myeloid-dependent suppressor cells (gMDSCs). The results suggest that MRC1 plays a critical role in myeloid plasticity, which in turn affects the adaptive immune response and immunopathogenesis during murine NCC.<\/jats:p>","DOI":"10.1128\/iai.01176-12","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T04:54:12Z","timestamp":1358225652000},"page":"1052-1063","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Increased Accumulation of Regulatory Granulocytic Myeloid Cells in Mannose Receptor C Type 1-Deficient Mice Correlates with Protection in a Mouse Model of Neurocysticercosis"],"prefix":"10.1128","volume":"81","author":[{"given":"Pramod Kumar","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny A.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid E.","family":"Cardona","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy M.","family":"Teale","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, Texas, USA"},{"name":"Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70194-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14117-7"},{"key":"e_1_3_2_4_2","first-page":"830","article-title":"Symptomatic human neurocysticercosis\u2014age, sex and exposure factors relating with disease heterogeneity","volume":"251","author":"Fleury A","year":"2004","unstructured":"FleuryADesseinAPreuxPMDumasMTapiaGLarraldeCSciuttoE. 2004. Symptomatic human neurocysticercosis\u2014age, sex and exposure factors relating with disease heterogeneity. J. Neurol. 251:830\u2013837.","journal-title":"J. Neurol."},{"key":"e_1_3_2_5_2","first-page":"331","article-title":"Clinical manifestations of neurocysticercosis","volume":"24","author":"San-Juan Orta D","year":"2009","unstructured":"San-Juan OrtaD. 2009. Clinical manifestations of neurocysticercosis. Neurologia 24:331\u2013335. (In Spanish.)","journal-title":"Neurologia"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000058663"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.187"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238514.51747.3a"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00101-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000218"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"995","DOI":"10.4049\/jimmunol.162.2.995","article-title":"Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells","volume":"162","author":"Cardona AE","year":"1999","unstructured":"CardonaAERestrepoBIJaramilloJMTealeJM. 1999. Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells. J. Immunol. 162:995\u20131002.","journal-title":"J. Immunol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00256-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00112-X"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4554-4560.2001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3163"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.1412"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2569"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.01.002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00786.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00920-10"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.09.029"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00095-08"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000866"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.02.006"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0409242"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2008.11.004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(02)00250-5"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069540"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.11.020"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00455-09"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-118497"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100421"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-011-0039-z"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081073"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2634-2642.2003"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.07.010"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.04.003"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568007053544101"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0311177"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040911"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.08.001"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4666"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.276"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.06.003"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.03.036"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000090680.07515.C8"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.006"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1668"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00794.x"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1922-07.2007"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.06.073"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.09.017"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-118984"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001224"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0111021"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.004"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084545"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-006-0274-z"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh246"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.07.015"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.12.009"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00057-6"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-009-9170-6"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152710791012053"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-010-0151-4"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040895"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/262609"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.00973.x"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.11.006"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903636"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01176-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01176-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T17:52:40Z","timestamp":1687974760000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01176-12"}},"subtitle":[],"editor":[{"suffix":"Jr.","given":"J. F.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1128\/IAI.01176-12"],"URL":"https:\/\/doi.org\/10.1128\/iai.01176-12","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"2012-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}