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Among the genes in this island are\n            <jats:italic>ybtP<\/jats:italic>\n            and\n            <jats:italic>ybtQ<\/jats:italic>\n            , encoding distinctive ATP binding cassette (ABC) proteins associated with iron(III)-yersiniabactin import in\n            <jats:named-content content-type=\"genus-species\">Yersinia pestis<\/jats:named-content>\n            . In this study, we compared the impact of\n            <jats:italic>ybtPQ<\/jats:italic>\n            on a model\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            cystitis strain during\n            <jats:italic>in vitro<\/jats:italic>\n            culture and experimental murine infections. A\n            <jats:italic>ybtPQ<\/jats:italic>\n            -null mutant exhibited no growth defect under standard culture conditions, consistent with nonessentiality in this background. A growth defect phenotype was observed and genetically complemented\n            <jats:italic>in vitro<\/jats:italic>\n            during iron(III)-yersiniabactin-dependent growth. Following inoculation into the bladders of C3H\/HEN and C3H\/HeOuJ mice, this strain exhibited a profound, 10\n            <jats:sup>6<\/jats:sup>\n            -fold competitive infection defect in the subgroup of mice that progressed to high-titer bladder infections. These results identify a virulence role for YbtPQ in the highly inflammatory microenvironment characteristic of high-titer cystitis. The profound competitive defect may relate to the apparent selection of\n            <jats:named-content content-type=\"genus-species\">Yersinia<\/jats:named-content>\n            HPI-positive\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            in uncomplicated clinical UTIs.\n          <\/jats:p>","DOI":"10.1128\/iai.01211-15","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T03:58:22Z","timestamp":1455681502000},"page":"1312-1319","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["The Yersiniabactin-Associated ATP Binding Cassette Proteins YbtP and YbtQ Enhance Escherichia coli Fitness during High-Titer Cystitis"],"prefix":"10.1128","volume":"84","author":[{"given":"Eun-Ik","family":"Koh","sequence":"first","affiliation":[{"name":"Center for Women's Infectious Diseases Research, Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia S.","family":"Hung","sequence":"additional","affiliation":[{"name":"Center for Women's Infectious Diseases Research, Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Center for Women's Infectious Diseases Research, Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01054-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.190"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis252"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010170"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/600385"},{"key":"e_1_3_3_7_2","first-page":"1","article-title":"Recurrent urinary infections in adult women. 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