{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:31:12Z","timestamp":1793280672156,"version":"4.5.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Helminth infections have been associated with protection against allergy and autoimmune diseases. We investigated the effects of chronic infections with\n                    <jats:italic>Ascaris lumbricoides<\/jats:italic>\n                    and\n                    <jats:italic>Trichuris trichiura<\/jats:italic>\n                    (measured twice over a 5-year period) on cytokine and antibody responses. We collected blood from 1,060 children aged 4 to 11 years living in a poor urban area of Brazil and measured Th1 (gamma interferon [IFN-\u03b3]) and Th2 (interleukin-5 [IL-5] and IL-13) cytokines and the regulatory cytokine IL-10 in unstimulated and stimulated (with mitogen or\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>lumbricoides<\/jats:italic>\n                    antigens) cultures of peripheral blood leukocytes and levels of total IgE and anti-\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>lumbricoides<\/jats:italic>\n                    IgG4 and IgE in serum. Intestinal helminth infections were associated with an increased proportion of children producing IL-5 in response to\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>lumbricoides<\/jats:italic>\n                    and producing IL-10 spontaneously, especially among coinfected and chronically infected children. Helminth infections were associated with a generalized suppression of cytokine responses to mitogen. Levels of total IgE and anti-\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>lumbricoides<\/jats:italic>\n                    IgG4 and IgE were especially elevated in chronically infected children. In conclusion, intestinal helminth infections were associated with a typical Th2 immune response profile and with the induction of immune hyporesponsiveness that was associated with greater frequencies of the production of spontaneous IL-10.\n                  <\/jats:p>","DOI":"10.1128\/iai.01228-09","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T22:25:59Z","timestamp":1271715959000},"page":"3160-3167","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":137,"title":["Chronic Intestinal Helminth Infections Are Associated with Immune Hyporesponsiveness and Induction of a Regulatory Network"],"prefix":"10.1128","volume":"78","author":[{"given":"Camila Alexandrina","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Instituto de Cie\u0302ncias da Sau\u0301de, Universidade Federal da Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio L.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Instituto de Sau\u0301de Coletiva, Universidade Federal de Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Centre for Infection, St. George's University of London, London, United Kingdom"},{"name":"Instituto de Microbiologia, Universidad San Francisco de Quito, Quito, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni\u0301vea Bispo","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Sau\u0301de Coletiva, Universidade Federal de Bahia, Salvador, Brazil"},{"name":"Instituto de Matema\u0301tica, Universidade Federal da Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila D.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Instituto de Matema\u0301tica, Universidade Federal da Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neuza Maria","family":"Alcantara-Neves","sequence":"additional","affiliation":[{"name":"Instituto de Cie\u0302ncias da Sau\u0301de, Universidade Federal da Bahia, Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Introduction to categorical data analysis 2007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.6.769"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/425017"},{"key":"e_1_3_2_5_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61638-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-6-15"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.10.1625"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/591945"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/515661"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32831f44a6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2006.05.073"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03515.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800366"},{"key":"e_1_3_2_15_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/es053368a"},{"key":"e_1_3_2_17_2","unstructured":"Nondetects and data analysis: statistics for censored environmental data 2005"},{"key":"e_1_3_2_18_2","first-page":"281","volume":"9","year":"1934","unstructured":"Hoffman, W. A., J. A. Pons, and J. L. Janer. 1934. The sedimentation-concentration method in schistosomiasis mansoni. Puerto Rico J. Public Health9:281-298.","journal-title":"Puerto Rico J. Public Health"},{"key":"e_1_3_2_19_2","first-page":"397","volume":"14","year":"1972","unstructured":"Katz, N., A. Chaves, and J. Pellegrino. 1972. A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. Rev. Inst. Med. Trop. Sao Paulo14:397-400.","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cageo.2006.09.006"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1183"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00994.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.00983.x"},{"key":"e_1_3_2_25_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.5.2598-2604.2004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00783-07"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00187.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61070-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/j.1365-2222.2008.03027.x","volume":"38","year":"2008","unstructured":"Rodrigues, L. C., P. J. Newcombe, S. S. Cunha, N. M. Alcantara-Neves, B. Genser, A. A. Cruz, S. M. Simoes, R. Fiaccone, L. Amorim, P. J. Cooper, M. L. Barreto, and Social Change, Asthma and Allergy in Latin America. 2008. Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood. Clin. Exp. Allergy38:1769-1777.","journal-title":"Clin. Exp. Allergy"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.1.269"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701436765"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg075"},{"key":"e_1_3_2_35_2","unstructured":"Modeling survival data: extending the Cox model 2000"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1086\/586717"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042572"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5567.490"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00879.x"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01228-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01228-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T18:45:11Z","timestamp":1711392311000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01228-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1128\/IAI.01228-09"],"URL":"https:\/\/doi.org\/10.1128\/iai.01228-09","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"2009-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}