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It is likely that<jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>spp. have evolved mechanisms to avoid the CD8<jats:sup>+<\/jats:sup>killer T cell responses by interfering with MHC class I antigen presentation. Using a model system of self-peptide presentation which allows for posttranslational control of the model protein's stability, we tested the ability of various<jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>species to alter direct MHC class I antigen presentation. Infection of the JY lymphoblastoid cell line limited the accumulation of a model host protein and increased presentation of the model-protein-derived peptides. Enhanced self-peptide presentation was detected only when presentation was restricted to<jats:underline>d<\/jats:underline>efective<jats:underline>ri<\/jats:underline>bosomal<jats:underline>p<\/jats:underline>roducts, or DRiPs, and total MHC class I levels remained unaltered. Skewed antigen presentation was dependent on a bacterial synthesized component, as evidenced by reversal of the observed phenotype upon preventing bacterial transcription, translation, and the inhibition of bacterial lipooligosaccharide synthesis. These data suggest that<jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>spp. have evolved to alter the host antigen presentation machinery to favor presentation of defective and rapidly degraded forms of self-antigen, possibly as a mechanism to diminish the presentation of peptides derived from bacterial proteins.<\/jats:p>","DOI":"10.1128\/iai.01254-15","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T02:59:20Z","timestamp":1448333960000},"page":"480-490","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Enhanced Direct Major Histocompatibility Complex Class I Self-Antigen Presentation Induced by Chlamydia Infection"],"prefix":"10.1128","volume":"84","author":[{"given":"Erik D.","family":"Cram","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan S.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D.","family":"Rockey","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-1887","authenticated-orcid":false,"given":"Brian P.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.08.006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1565-1572.2006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.7285"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/652397"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2575"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01301.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/315856"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/420905"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.9.1525"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.22"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00707-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.08.012"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.T500014-MCP200"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.68"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/3-540-30791-5_9","volume-title":"Molecular mimicry: infection-inducing autoimmune disease","author":"Bachmaier K","year":"2005","unstructured":"Bachmaier K, Penninger JM. 2005. 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